{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"submitter":["Creighton CJ"],"pagination":["R28"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-3834"],"project":["EurocanPlatform"],"abstract":["We generated DNA microarray based gene expression profiles from three estrogen receptor a (ERa) positive breast cancer cell lines stimulated by 17ß-estradiol (E2) in vitro over a time course, as well as from MCF-7 cells grown as xenografts in ovariectomized athymic nude mice with E2 supplementation and after its withdrawal. Experiment Overall Design: 8 MCF-7 xenograft profiles (4 with E2,4 without E2), 14 T47D profiles (with E2 treatment in culture from 0 to 24 hr), 10 BT-474 profiles (with E2 treatment from 0 to 24 hr), 12 MCf-7 profiles (with E2 treatment from 0 to 24 hr)"],"repository":["biostudies-other"],"experiment_type":["transcription profiling by array"],"data_source":["EurocanPlatform"],"omics_type":["Unknown"],"volume":["7"],"journal":["Genome biology"],"species":["Homo sapiens"],"pubmed_authors":["Larios JM","Miller RS","Cordero KE","Johnson MD","Creighton CJ","Lippman ME","Chinnaiyan AM","Rae JM"],"additional_accession":[]},"is_claimable":false,"name":"Transcription profiling of human ER+ BrC cells with and without estradiol in both cell cultures and xenografts","description":"We generated DNA microarray based gene expression profiles from three estrogen receptor a (ERa) positive breast cancer cell lines stimulated by 17ß-estradiol (E2) in vitro over a time course, as well as from MCF-7 cells grown as xenografts in ovariectomized athymic nude mice with E2 supplementation and after its withdrawal. Experiment Overall Design: 8 MCF-7 xenograft profiles (4 with E2,4 without E2), 14 T47D profiles (with E2 treatment in culture from 0 to 24 hr), 10 BT-474 profiles (with E2 treatment from 0 to 24 hr), 12 MCf-7 profiles (with E2 treatment from 0 to 24 hr)","dates":{"release":"2016-04-14T14:11:49Z","publication":"2006","modification":"2016-04-14T14:11:49Z","creation":"2016-04-14T14:11:49Z"},"accession":"S-ECPF-GEOD-3834","cross_references":{"GEO":["GSE3834"],"ArrayExpress":["E-GEOD-3834"],"EFO":["EFO_0000305","EFO_0000322"],"ArrayExpress files":["E-GEOD-3834"]}}