{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"submitter":["Wang Y"],"pagination":["5396-5406"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-38583"],"project":["EurocanPlatform"],"abstract":["The tumor microenvironment is characterized by low glucose and hypoxia. It is well known that changes in the tumor microenvironment, such as hypoxia and low glucose, can increase the production of VEGF. Although the role of hypoxia in the regulation of VEGF production is well understood, the mechanism linking glucose deprivation (GD) to tumor growth and angiogenesis is unclear. Here, GD (a physiological stimulus) was used to treat human tumor cells. The transcriptional reprogramming of tumor cells by GD was measured with microarray technology to provide a comprehensive analysis of the gene expression profile underlying the GD treatment. Our study suggested that GD initiates an angiogenic switch by increasing the expression of proangiogenic mediators  (VEGF, FGF2, IL6, etc.) and decreasing "],"repository":["biostudies-other"],"experiment_type":["transcription profiling by array"],"data_source":["EurocanPlatform"],"omics_type":["Unknown"],"volume":["72"],"journal":["Cancer research"],"species":["Homo sapiens"],"pubmed_authors":["Polverini PJ","Dong Z","Ning Y","Visioli F","Alam GN","Nör JE","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"Expression analysis of the glucose deprivation-induced human tumor cell responses","description":"The tumor microenvironment is characterized by low glucose and hypoxia. It is well known that changes in the tumor microenvironment, such as hypoxia and low glucose, can increase the production of VEGF. Although the role of hypoxia in the regulation of VEGF production is well understood, the mechanism linking glucose deprivation (GD) to tumor growth and angiogenesis is unclear. Here, GD (a physiological stimulus) was used to treat human tumor cells. The transcriptional reprogramming of tumor cells by GD was measured with microarray technology to provide a comprehensive analysis of the gene expression profile underlying the GD treatment. Our study suggested that GD initiates an angiogenic switch by increasing the expression of proangiogenic mediators  (VEGF, FGF2, IL6, etc.) and decreasing ","dates":{"release":"2016-04-14T14:12:06Z","publication":"2012 Oct","modification":"2016-04-14T14:12:06Z","creation":"2016-04-14T14:12:06Z"},"accession":"S-ECPF-GEOD-38583","cross_references":{"GEO":["GSE38583"],"ArrayExpress":["E-GEOD-38583"],"EFO":["EFO_0000199","EFO_0000322"],"ArrayExpress files":["E-GEOD-38583"]}}