{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"submitter":["Persson H"],"pagination":["78-86"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-39162"],"project":["EurocanPlatform"],"abstract":["To comprehensively characterize microRNA (miRNA) expression in breast cancer, we performed the first extensive next-generation sequencing expression analysis of this disease. We sequenced small RNA from tumors with paired samples of normal and tumor-adjacent breast tissue. Our results indicate that tumor identity is achieved mainly by variation in the expression levels of a common set of miRNAs rather than by tissue-specific expression. We also report 361 new, well-supported miRNA precursors. Nearly two-thirds of these new genes were detected in other human tissues and 49% of the miRNAs were found associated with Ago2 in MCF7 cells. Ten percent of the new miRNAs are located in regions with high-level genomic amplifications in breast cancer. A new miRNA is encoded within the ERBB2/Her2 gene"],"repository":["biostudies-other"],"experiment_type":["RNA-seq of non coding RNA"],"data_source":["EurocanPlatform"],"omics_type":["Unknown"],"volume":["71"],"journal":["Cancer research"],"species":["Homo sapiens"],"pubmed_authors":["Persson H","Jonsson G","Borg A","Luts L","Rego N","Staaf J","Loman N","Naya H","Kvist A","Vallon-Christersson J","Rovira C","Hoglund M"],"additional_accession":[]},"is_claimable":false,"name":"Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene","description":"To comprehensively characterize microRNA (miRNA) expression in breast cancer, we performed the first extensive next-generation sequencing expression analysis of this disease. We sequenced small RNA from tumors with paired samples of normal and tumor-adjacent breast tissue. Our results indicate that tumor identity is achieved mainly by variation in the expression levels of a common set of miRNAs rather than by tissue-specific expression. We also report 361 new, well-supported miRNA precursors. Nearly two-thirds of these new genes were detected in other human tissues and 49% of the miRNAs were found associated with Ago2 in MCF7 cells. Ten percent of the new miRNAs are located in regions with high-level genomic amplifications in breast cancer. A new miRNA is encoded within the ERBB2/Her2 gene","dates":{"release":"2016-04-14T14:12:44Z","publication":"2011 Jan","modification":"2016-04-14T14:12:44Z","creation":"2016-04-14T14:12:44Z"},"accession":"S-ECPF-GEOD-39162","cross_references":{"GEO":["GSE39162"],"ArrayExpress":["E-GEOD-39162"],"EFO":["EFO_0000635","EFO_0000305"],"ArrayExpress files":["E-GEOD-39162"]}}