{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"submitter":["Coldren CD"],"pagination":["521-528"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-4342"],"project":["EurocanPlatform"],"abstract":["Eleven NSCLC cell lines with widely divergent gefitinib sensitivities were compared using gene expression.  Genes associated with gefitinib response were used to classify additional NSCLC lines with unknown gefitnib sensitivity. A subset of the test set data was tested for gefitinib sensitivity, and results correlated strongly with the gene expression-based predictions; All eleven training set lines, and seven test set lines had both HGU133A and B chips done, while other test set lines had only HGU133As. Experiment Overall Design: Baseline (unstimulated) gene expression was measured in a large panel of NSCLC cell lines."],"repository":["biostudies-other"],"experiment_type":["transcription profiling by array"],"data_source":["EurocanPlatform"],"omics_type":["Unknown"],"volume":["4"],"journal":["Molecular cancer research : MCR"],"species":["Homo sapiens"],"pubmed_authors":["Zeng C","Lapadat R","Helfrich BA","Hirsch FR","Sugita M","Witta SE","Geraci MW","Coldren CD","Franklin WA","Barón A","Bunn PA Jr"],"additional_accession":[]},"is_claimable":false,"name":"Transcription profiling of non squamous cell lung cancer cell lines to investigate sensititivity to gefitinib and predict this in previously untested cell lines","description":"Eleven NSCLC cell lines with widely divergent gefitinib sensitivities were compared using gene expression.  Genes associated with gefitinib response were used to classify additional NSCLC lines with unknown gefitnib sensitivity. A subset of the test set data was tested for gefitinib sensitivity, and results correlated strongly with the gene expression-based predictions; All eleven training set lines, and seven test set lines had both HGU133A and B chips done, while other test set lines had only HGU133As. Experiment Overall Design: Baseline (unstimulated) gene expression was measured in a large panel of NSCLC cell lines.","dates":{"release":"2016-04-14T14:19:38Z","publication":"2006 Aug","modification":"2016-04-14T14:19:38Z","creation":"2016-04-14T14:19:38Z"},"accession":"S-ECPF-GEOD-4342","cross_references":{"GEO":["GSE4342"],"ArrayExpress":["E-GEOD-4342"],"EFO":["EFO_0000322","EFO_0001071"],"ArrayExpress files":["E-GEOD-4342"]}}