biostudies-otherColdren CD521-528https://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-4342EurocanPlatformEleven NSCLC cell lines with widely divergent gefitinib sensitivities were compared using gene expression. Genes associated with gefitinib response were used to classify additional NSCLC lines with unknown gefitnib sensitivity. A subset of the test set data was tested for gefitinib sensitivity, and results correlated strongly with the gene expression-based predictions; All eleven training set lines, and seven test set lines had both HGU133A and B chips done, while other test set lines had only HGU133As. Experiment Overall Design: Baseline (unstimulated) gene expression was measured in a large panel of NSCLC cell lines.biostudies-othertranscription profiling by arrayEurocanPlatformUnknown4Molecular cancer research : MCRHomo sapiensZeng CLapadat RHelfrich BAHirsch FRSugita MWitta SEGeraci MWColdren CDFranklin WABarón ABunn PA JrfalseTranscription profiling of non squamous cell lung cancer cell lines to investigate sensititivity to gefitinib and predict this in previously untested cell linesEleven NSCLC cell lines with widely divergent gefitinib sensitivities were compared using gene expression. Genes associated with gefitinib response were used to classify additional NSCLC lines with unknown gefitnib sensitivity. A subset of the test set data was tested for gefitinib sensitivity, and results correlated strongly with the gene expression-based predictions; All eleven training set lines, and seven test set lines had both HGU133A and B chips done, while other test set lines had only HGU133As. Experiment Overall Design: Baseline (unstimulated) gene expression was measured in a large panel of NSCLC cell lines.2016-04-14T14:19:38Z2006 Aug2016-04-14T14:19:38Z2016-04-14T14:19:38ZS-ECPF-GEOD-4342GSE4342E-GEOD-4342EFO_0000322EFO_0001071E-GEOD-4342