{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"submitter":["Nair R"],"pagination":["3992-4002"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-43730"],"project":["EurocanPlatform"],"abstract":["The HER2 (ERBB2) and MYC genes are commonly amplified genes in breast cancer, yet little is known about their molecular and clinical interaction. Using a novel chimeric mammary transgenic approach and in vitro models, we demonstrate markedly increased self renewal and tumour propagating capability of cells transformed with Her2 and c-Myc. Co-expression of both oncogenes in cultured cells led to a pronounced activation of a c-Myc transcriptional signature and acquisition of a self renewing phenotype independent of an EMT programme or regulation of cancer stem cell markers. We show that HER2 and c-MYC are frequently co-amplified in a clinical breast cancer cohort and that co-amplification is strongly associated with aggressive clinical behaviour and poor outcome. Lastly, we show that in pati"],"repository":["biostudies-other"],"experiment_type":["transcription profiling by array"],"data_source":["EurocanPlatform"],"omics_type":["Unknown"],"volume":["33"],"journal":["Oncogene"],"species":["Homo sapiens"],"pubmed_authors":["Roden DL","Perou CM","Nair R","Naylor MJ","O'Toole SA","Shah J","Swarbrick A","Ormandy CJ","McFarland A","Morey A","Yang J","Hui M","Kaplan W","Teo WS","Cowley MJ","Nikolic I","Herschkowitz JI","Usary J","Lakhani SR","Selinger C","Ye S","Pfefferle AD","Baker LA","Junankar S","Nguyen A","Armstrong N"],"additional_accession":[]},"is_claimable":false,"name":"A Myc transcriptional program that is independent of EMT drives a poor prognosis tumor-propagating phenotype in HER2+ breast cancer","description":"The HER2 (ERBB2) and MYC genes are commonly amplified genes in breast cancer, yet little is known about their molecular and clinical interaction. Using a novel chimeric mammary transgenic approach and in vitro models, we demonstrate markedly increased self renewal and tumour propagating capability of cells transformed with Her2 and c-Myc. Co-expression of both oncogenes in cultured cells led to a pronounced activation of a c-Myc transcriptional signature and acquisition of a self renewing phenotype independent of an EMT programme or regulation of cancer stem cell markers. We show that HER2 and c-MYC are frequently co-amplified in a clinical breast cancer cohort and that co-amplification is strongly associated with aggressive clinical behaviour and poor outcome. Lastly, we show that in pati","dates":{"release":"2016-04-14T14:20:13Z","publication":"2014 Jul","modification":"2016-04-14T14:20:13Z","creation":"2016-04-14T14:20:13Z"},"accession":"S-ECPF-GEOD-43730","cross_references":{"GEO":["GSE43730"],"ArrayExpress":["E-GEOD-43730"],"EFO":["EFO_0000305","EFO_0000322"],"ArrayExpress files":["E-GEOD-43730"]}}