{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"submitter":["Wang L"],"pagination":["2035"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-46632"],"project":["EurocanPlatform"],"abstract":["JIB-04 is an inhibitor of Jumonji histone demethylases identified through a cell based screen that measures the reactivation of an epigenetically silenced transgene. The active JIB-04 E-isomer shows selectivity for cancer vs. normal cells affecting both transcriptional patterns and cell viability in a cancer specific manner. H358 lung cancer cells or the patient matched HCC4017 (cancer) vs. HBEC30KT (immortalized normal) lung cell pair were treated with DMSO vehicle or 500nM E-isomer or 500 nM Z-isomer of JIB-04 for 4 h or 24 h and RNA extracted."],"repository":["biostudies-other"],"experiment_type":["transcription profiling by array"],"data_source":["EurocanPlatform"],"omics_type":["Unknown"],"volume":["4"],"journal":["Nature communications"],"species":["Homo sapiens"],"pubmed_authors":["Easmon J","Quinn AM","Brekken RA","Martinez ED","Peña-Llopis S","Frantz DE","Babinski DJ","Varghese D","Dellinger M","Xu J","Wang L","Kumar S","Bruick R","Ruiz J","Best AM","Simeonov A","Chang J"],"additional_accession":[]},"is_claimable":false,"name":"Identification of genes modulated by JIB-04 in lung cancer cells","description":"JIB-04 is an inhibitor of Jumonji histone demethylases identified through a cell based screen that measures the reactivation of an epigenetically silenced transgene. The active JIB-04 E-isomer shows selectivity for cancer vs. normal cells affecting both transcriptional patterns and cell viability in a cancer specific manner. H358 lung cancer cells or the patient matched HCC4017 (cancer) vs. HBEC30KT (immortalized normal) lung cell pair were treated with DMSO vehicle or 500nM E-isomer or 500 nM Z-isomer of JIB-04 for 4 h or 24 h and RNA extracted.","dates":{"release":"2016-04-14T14:24:13Z","publication":"2013","modification":"2016-04-14T14:24:13Z","creation":"2016-04-14T14:24:13Z"},"accession":"S-ECPF-GEOD-46632","cross_references":{"GEO":["GSE46632"],"ArrayExpress":["E-GEOD-46632"],"EFO":["EFO_0000322","EFO_0001071"],"ArrayExpress files":["E-GEOD-46632"]}}