biostudies-otherWang L2035https://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-46632EurocanPlatformJIB-04 is an inhibitor of Jumonji histone demethylases identified through a cell based screen that measures the reactivation of an epigenetically silenced transgene. The active JIB-04 E-isomer shows selectivity for cancer vs. normal cells affecting both transcriptional patterns and cell viability in a cancer specific manner. H358 lung cancer cells or the patient matched HCC4017 (cancer) vs. HBEC30KT (immortalized normal) lung cell pair were treated with DMSO vehicle or 500nM E-isomer or 500 nM Z-isomer of JIB-04 for 4 h or 24 h and RNA extracted.biostudies-othertranscription profiling by arrayEurocanPlatformUnknown4Nature communicationsHomo sapiensEasmon JQuinn AMBrekken RAMartinez EDPeña-Llopis SFrantz DEBabinski DJVarghese DDellinger MXu JWang LKumar SBruick RRuiz JBest AMSimeonov AChang JfalseIdentification of genes modulated by JIB-04 in lung cancer cellsJIB-04 is an inhibitor of Jumonji histone demethylases identified through a cell based screen that measures the reactivation of an epigenetically silenced transgene. The active JIB-04 E-isomer shows selectivity for cancer vs. normal cells affecting both transcriptional patterns and cell viability in a cancer specific manner. H358 lung cancer cells or the patient matched HCC4017 (cancer) vs. HBEC30KT (immortalized normal) lung cell pair were treated with DMSO vehicle or 500nM E-isomer or 500 nM Z-isomer of JIB-04 for 4 h or 24 h and RNA extracted.2016-04-14T14:24:13Z20132016-04-14T14:24:13Z2016-04-14T14:24:13ZS-ECPF-GEOD-46632GSE46632E-GEOD-46632EFO_0000322EFO_0001071E-GEOD-46632