{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Shioda Toshi"],"species":["Homo sapiens"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-50705"],"project":["EurocanPlatform"],"abstract":["Transcriptome analysis of MCF-7 cells exposed for 48 hours to various concentrations of xenoestrogen chemicals. Although biological effects of endocrine disrupting chemicals (EDCs) are often observed at unexpectedly low doses with occasional non-monotonic dose-response characteristics, transcriptome-wide profiles of sensitivities or dose-dependent behaviors of the EDC responsive genes have remained unexplored. Here, we describe expressome analysis for the comprehensive examination of dose-dependent gene responses and its applications to characterize estrogen responsive genes in MCF-7 cells. Transcriptomes of MCF-7 cells exposed to varying concentrations of representative natural and xenobiotic estrogens for 48 hours were determined by microarray and used for computational calculation of in"],"repository":["biostudies-other"],"experiment_type":["transcription profiling by array"],"data_source":["EurocanPlatform"],"pubmed_authors":["Suto Mizuki","Carey Vincent","Coser Kathryn","Isselbacher Kurt","Rosenthal Noël","Phatak Mukta","Shioda Toshi","Medvedovic Mario"],"additional_accession":[]},"is_claimable":false,"name":"Xenoestrogen Dose-dependent Transcriptomal Changes in MCF-7 Human Breast Cancer Cells","description":"Transcriptome analysis of MCF-7 cells exposed for 48 hours to various concentrations of xenoestrogen chemicals. Although biological effects of endocrine disrupting chemicals (EDCs) are often observed at unexpectedly low doses with occasional non-monotonic dose-response characteristics, transcriptome-wide profiles of sensitivities or dose-dependent behaviors of the EDC responsive genes have remained unexplored. Here, we describe expressome analysis for the comprehensive examination of dose-dependent gene responses and its applications to characterize estrogen responsive genes in MCF-7 cells. Transcriptomes of MCF-7 cells exposed to varying concentrations of representative natural and xenobiotic estrogens for 48 hours were determined by microarray and used for computational calculation of in","dates":{"release":"2016-04-14T14:29:35Z","modification":"2016-04-14T14:29:35Z","creation":"2016-04-14T14:29:35Z"},"accession":"S-ECPF-GEOD-50705","cross_references":{"GEO":["GSE50705"],"ArrayExpress":["E-GEOD-50705"],"EFO":["EFO_0000305","EFO_0000322"],"ArrayExpress files":["E-GEOD-50705"]}}