biostudies-otherUnknownShioda ToshiHomo sapienshttps://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-50705EurocanPlatformTranscriptome analysis of MCF-7 cells exposed for 48 hours to various concentrations of xenoestrogen chemicals. Although biological effects of endocrine disrupting chemicals (EDCs) are often observed at unexpectedly low doses with occasional non-monotonic dose-response characteristics, transcriptome-wide profiles of sensitivities or dose-dependent behaviors of the EDC responsive genes have remained unexplored. Here, we describe expressome analysis for the comprehensive examination of dose-dependent gene responses and its applications to characterize estrogen responsive genes in MCF-7 cells. Transcriptomes of MCF-7 cells exposed to varying concentrations of representative natural and xenobiotic estrogens for 48 hours were determined by microarray and used for computational calculation of inbiostudies-othertranscription profiling by arrayEurocanPlatformSuto MizukiCarey VincentCoser KathrynIsselbacher KurtRosenthal NoëlPhatak MuktaShioda ToshiMedvedovic MariofalseXenoestrogen Dose-dependent Transcriptomal Changes in MCF-7 Human Breast Cancer CellsTranscriptome analysis of MCF-7 cells exposed for 48 hours to various concentrations of xenoestrogen chemicals. Although biological effects of endocrine disrupting chemicals (EDCs) are often observed at unexpectedly low doses with occasional non-monotonic dose-response characteristics, transcriptome-wide profiles of sensitivities or dose-dependent behaviors of the EDC responsive genes have remained unexplored. Here, we describe expressome analysis for the comprehensive examination of dose-dependent gene responses and its applications to characterize estrogen responsive genes in MCF-7 cells. Transcriptomes of MCF-7 cells exposed to varying concentrations of representative natural and xenobiotic estrogens for 48 hours were determined by microarray and used for computational calculation of in2016-04-14T14:29:35Z2016-04-14T14:29:35Z2016-04-14T14:29:35ZS-ECPF-GEOD-50705GSE50705E-GEOD-50705EFO_0000305EFO_0000322E-GEOD-50705