biostudies-otherUnknownSalt MeganHomo sapienshttps://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-52308EurocanPlatformTumors that show evidence of epithelial to mesenchymal transition (EMT) have been associated with metastasis, drug resistance, and poor prognosis. EMT may alter the molecular requirements for growth and survival in different contexts, but the underlying mechanisms remain incomplete. Given the heterogeneity along the EMT spectrum between and within tumors it is important to define the requirements for growth and survival in cells with an epithelial or mesenchymal phenotype to maximize therapeutic efficacy. We have established an inducible cell line model in which a tamoxifen regulatable Twist-ER fusion protein is stably expressed in the H358 non-small cell lung cancer cell line. Upon tamoxifen addition, cells undergo EMT and provide a system in which we can compare the growth and survivabiostudies-othertranscription profiling by arrayEurocanPlatformSalt MeganMcCormick FrankBandyopadhyay SouravfalseExpression data from H358Tumors that show evidence of epithelial to mesenchymal transition (EMT) have been associated with metastasis, drug resistance, and poor prognosis. EMT may alter the molecular requirements for growth and survival in different contexts, but the underlying mechanisms remain incomplete. Given the heterogeneity along the EMT spectrum between and within tumors it is important to define the requirements for growth and survival in cells with an epithelial or mesenchymal phenotype to maximize therapeutic efficacy. We have established an inducible cell line model in which a tamoxifen regulatable Twist-ER fusion protein is stably expressed in the H358 non-small cell lung cancer cell line. Upon tamoxifen addition, cells undergo EMT and provide a system in which we can compare the growth and surviva2016-04-14T14:32:05Z2016-04-14T14:32:05Z2016-04-14T14:32:05ZS-ECPF-GEOD-52308GSE52308E-GEOD-52308EFO_0003060EFO_0000322E-GEOD-52308