biostudies-otherShames DSe486https://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-5816EurocanPlatformAbstract; Background: Promoter hypermethylation coupled with loss of heterozygosity at the same locus results in loss of gene function in many tumor cells. The “rules” governing which genes are methylated during the pathogenesis of individual cancers, how specific methylation profiles are initially established, or what determines tumor-type specific methylation are unknown. However, DNA methylation markers that are highly specific and sensitive for common tumors would be useful for the early detection of cancer, and those required for the malignant phenotype identify pathways important as therapeutic targets. Methods and Findings: In an effort to identify new cancer-specific methylation markers, we employed a high throughput global expression profiling approach in lung cancer cells. biostudies-othertranscription profiling by arrayEurocanPlatformUnknown3PLoS medicineHomo sapiensGao BNanda RGazdar AFGerald WLam CLShames DSPerou CMShay JWOlopade OIMinna JDShivapurkar NShyr YEuhus DMKim YHPollack JRJiang AGirard LSato MLewis CMFong KMWong MfalseTranscription profiling of lung cancer cells treated with 5-aza - a genome-wide screen for hypermethylated genes in lung cancerAbstract; Background: Promoter hypermethylation coupled with loss of heterozygosity at the same locus results in loss of gene function in many tumor cells. The “rules” governing which genes are methylated during the pathogenesis of individual cancers, how specific methylation profiles are initially established, or what determines tumor-type specific methylation are unknown. However, DNA methylation markers that are highly specific and sensitive for common tumors would be useful for the early detection of cancer, and those required for the malignant phenotype identify pathways important as therapeutic targets. Methods and Findings: In an effort to identify new cancer-specific methylation markers, we employed a high throughput global expression profiling approach in lung cancer cells. 2016-04-14T14:37:07Z2006 Dec2016-04-14T14:37:07Z2016-04-14T14:37:07ZS-ECPF-GEOD-5816GSE5816E-GEOD-5816EFO_0002660EFO_0001071E-GEOD-5816