{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(12)"],"submitter":["Higashiyama T"],"journal":["The EMBO journal"],"pagination":["3715-23"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1169995"],"abstract":["Six copies of insertion elements accumulate in the subtelomeric region immediately proximal to the telomeric repeats on Chlorella chromosome I. The elements, designated Zepps, bear the characteristic features of non-viral (LINE-like) retrotransposons, including a poly(A) tail, 5'-truncations, a retroviral reverse transcriptase-like ORF and flanking target duplications. Detailed sequence analysis of the Chlorella subtelomeric region revealed a novel mechanism of Zepp transposition; successive insertions of each Zepp element into another Zepp as a target, leaving a tandem array of their 3'-regions with poly(A) tracts facing toward the centromere. Only the most distal Zepp copy was inverted to connect its poly(A) tail with the telomeric repeats. A similar Zepp cluster but without the telomeric repeats was also found at the terminus of another Chlorella chromosome. These structures contrast with that proposed for the addition of HeT-A and TART elements to Drosophila telomeres. Expression of Zepp elements is induced by heat shock treatment. Possible roles of the subtelomeric retrotransposons in formation and maintenance of telomeres are discussed."],"repository":["biostudies-other"],"pmcid":["PMC1169995"],"data_source":["Europe PMC"],"pubmed_authors":["Higashiyama T","Noutoshi Y","Fujie M","Yamada T"],"additional_accession":[]},"is_claimable":false,"name":"Zepp, a LINE-like retrotransposon accumulated in the Chlorella telomeric region.","description":"Six copies of insertion elements accumulate in the subtelomeric region immediately proximal to the telomeric repeats on Chlorella chromosome I. The elements, designated Zepps, bear the characteristic features of non-viral (LINE-like) retrotransposons, including a poly(A) tail, 5'-truncations, a retroviral reverse transcriptase-like ORF and flanking target duplications. Detailed sequence analysis of the Chlorella subtelomeric region revealed a novel mechanism of Zepp transposition; successive insertions of each Zepp element into another Zepp as a target, leaving a tandem array of their 3'-regions with poly(A) tracts facing toward the centromere. Only the most distal Zepp copy was inverted to connect its poly(A) tail with the telomeric repeats. A similar Zepp cluster but without the telomeric repeats was also found at the terminus of another Chlorella chromosome. These structures contrast with that proposed for the addition of HeT-A and TART elements to Drosophila telomeres. Expression of Zepp elements is induced by heat shock treatment. Possible roles of the subtelomeric retrotransposons in formation and maintenance of telomeres are discussed.","dates":{"release":"1997-01-01T00:00:00Z","publication":"1997 Jun","modification":"2019-03-27T01:09:04Z","creation":"2019-03-27T01:09:04Z"},"accession":"S-EPMC1169995","cross_references":{"gen":["D89938","D26375","D82879"],"pubmed":["9218812"],"doi":["10.1093/emboj/16.12.3715 "]}}