biostudies-otherUnknown134(3)Infante JPThe Biochemical journal825-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC1177882The incorporation of choline into phosphatidylcholine in mammary tissue from lactating cows is impeded by 2-chloroethyltrimethylammonium chloride at concentrations ranging from 0.3 to 9mm. This compound is a non-competitive inhibitor of choline kinase (K(m) 0.25mm), having K(i) 17mm. It is suggested that 2-chloroethyltrimethylammonium chloride may inhibit choline entry into the tissue.biostudies-otherEurope PMCKinsella JEInfante JPfalseInhibition of phosphatidylcholine synthesis in mammary tissue by 2-chloroethyltrimethylammonium chloride.The incorporation of choline into phosphatidylcholine in mammary tissue from lactating cows is impeded by 2-chloroethyltrimethylammonium chloride at concentrations ranging from 0.3 to 9mm. This compound is a non-competitive inhibitor of choline kinase (K(m) 0.25mm), having K(i) 17mm. It is suggested that 2-chloroethyltrimethylammonium chloride may inhibit choline entry into the tissue.1973-01-01T00:00:00Z1973 Jul2019-08-04T08:06:55Z2019-08-04T08:06:55ZS-EPMC117788210.1042/bj1340825