{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(6)"],"submitter":["Hobert O"],"journal":["Molecular and cellular biology"],"pagination":["3066-73"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC231301"],"abstract":["The proto-oncogene product Vav plays a critical role in hematopoietic signal transduction. By using the yeast two-hybrid system, we identified a novel human protein, ENX-1, which interacts specifically with Vav both in vitro and in vivo. ENX-1 represents the human homolog of the Drosophila Enhancer of zeste gene, a member of the Polycomb group of genes, which are transcriptional regulators of homeobox gene expression. Interaction with ENX-1 suggests that Vav functions as an upstream element in the transcriptional regulation of homeobox genes, known to be important effectors in the hematopoietic system."],"repository":["biostudies-other"],"pmcid":["PMC231301"],"data_source":["Europe PMC"],"pubmed_authors":["Hobert O","Ullrich A","Jallal B"],"additional_accession":[]},"is_claimable":false,"name":"Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression.","description":"The proto-oncogene product Vav plays a critical role in hematopoietic signal transduction. By using the yeast two-hybrid system, we identified a novel human protein, ENX-1, which interacts specifically with Vav both in vitro and in vivo. ENX-1 represents the human homolog of the Drosophila Enhancer of zeste gene, a member of the Polycomb group of genes, which are transcriptional regulators of homeobox gene expression. Interaction with ENX-1 suggests that Vav functions as an upstream element in the transcriptional regulation of homeobox genes, known to be important effectors in the hematopoietic system.","dates":{"release":"1996-01-01T00:00:00Z","publication":"1996 Jun","modification":"2019-03-27T00:35:52Z","creation":"2019-03-27T00:35:52Z"},"accession":"S-EPMC231301","cross_references":{"gen":["U17564","U18007","U52965","U17552","U17563","U18003"],"pubmed":["8649418"],"doi":["10.1128/MCB.16.6.3066 "]}}