biostudies-otherUnknown16(6)Hobert OMolecular and cellular biology3066-73https://www.ebi.ac.uk/biostudies/studies/S-EPMC231301The proto-oncogene product Vav plays a critical role in hematopoietic signal transduction. By using the yeast two-hybrid system, we identified a novel human protein, ENX-1, which interacts specifically with Vav both in vitro and in vivo. ENX-1 represents the human homolog of the Drosophila Enhancer of zeste gene, a member of the Polycomb group of genes, which are transcriptional regulators of homeobox gene expression. Interaction with ENX-1 suggests that Vav functions as an upstream element in the transcriptional regulation of homeobox genes, known to be important effectors in the hematopoietic system.biostudies-otherPMC231301Europe PMCHobert OUllrich AJallal BfalseInteraction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression.The proto-oncogene product Vav plays a critical role in hematopoietic signal transduction. By using the yeast two-hybrid system, we identified a novel human protein, ENX-1, which interacts specifically with Vav both in vitro and in vivo. ENX-1 represents the human homolog of the Drosophila Enhancer of zeste gene, a member of the Polycomb group of genes, which are transcriptional regulators of homeobox gene expression. Interaction with ENX-1 suggests that Vav functions as an upstream element in the transcriptional regulation of homeobox genes, known to be important effectors in the hematopoietic system.1996-01-01T00:00:00Z1996 Jun2019-03-27T00:35:52Z2019-03-27T00:35:52ZS-EPMC231301U17564U18007U52965U17552U17563U18003864941810.1128/MCB.16.6.3066