biostudies-otherUnknown6(7-8)Maicas SComparative and Functional Genomics345-56https://www.ebi.ac.uk/biostudies/studies/S-EPMC2447501A total of 6047 open reading frames in the Candida albicans genome were screened for Zn(II)(2)C(6)-type zinc cluster proteins (or binuclear cluster proteins) involved in DNA recognition. These fungal proteins are transcription regulators of genes involved in a wide range of cellular processes, including metabolism of different compounds such as sugars or amino acids, as well as multi-drug resistance, control of meiosis, cell wall architecture, etc. The selection criteria used in the sequence analysis were the presence of the CysX(2)CysX(6)CysX(5-16)CysX(2)CysX(6-8)Cys motif and a putative nuclear localization signal. Using this approach, 70 putative Zn(II)(2)C(6) transcription factors have been found in the genome of C. albicans.biostudies-otherPMC2447501Europe PMCGomez MValentin EMoreno IMaicas SSentandreu RNieto AfalseIn silico analysis for transcription factors with Zn(II)(2)C(6) binuclear cluster DNA-binding domains in Candida albicans.A total of 6047 open reading frames in the Candida albicans genome were screened for Zn(II)(2)C(6)-type zinc cluster proteins (or binuclear cluster proteins) involved in DNA recognition. These fungal proteins are transcription regulators of genes involved in a wide range of cellular processes, including metabolism of different compounds such as sugars or amino acids, as well as multi-drug resistance, control of meiosis, cell wall architecture, etc. The selection criteria used in the sequence analysis were the presence of the CysX(2)CysX(6)CysX(5-16)CysX(2)CysX(6-8)Cys motif and a putative nuclear localization signal. Using this approach, 70 putative Zn(II)(2)C(6) transcription factors have been found in the genome of C. albicans.2005-01-01T00:00:00Z2005 2019-03-27T00:15:45Z2019-03-27T00:15:45ZS-EPMC244750118629206PF0408210.1002/cfg.492 1ew01PYC