biostudies-otherUnknown7Bonnafoux LBeilstein journal of organic chemistry1278-87https://www.ebi.ac.uk/biostudies/studies/S-EPMC3182437Regioselective bromine-lithium exchange reactions on polybrominated biaryls enable the modular synthesis of various polysubstituted biphenyls such as bis(dialkylphosphino)-, bis(diarylphosphino)- and dialkyl(diaryl)phosphinobiphenyls. All permutations of substituents at the ortho positions of the biphenyls are possible. In a similar manner, one can gain access to monophosphine analogues. So far, such a process, based on the effective discrimination between bromine atoms as a function of their chemical environment, has been observed only sporadically.biostudies-otherPMC3182437Europe PMCBonnafoux LLeroux FRColobert FfalseBromine-lithium exchange: An efficient tool in the modular construction of biaryl ligands.Regioselective bromine-lithium exchange reactions on polybrominated biaryls enable the modular synthesis of various polysubstituted biphenyls such as bis(dialkylphosphino)-, bis(diarylphosphino)- and dialkyl(diaryl)phosphinobiphenyls. All permutations of substituents at the ortho positions of the biphenyls are possible. In a similar manner, one can gain access to monophosphine analogues. So far, such a process, based on the effective discrimination between bromine atoms as a function of their chemical environment, has been observed only sporadically.2011-01-01T00:00:00Z2011 2019-03-26T22:30:21Z2019-03-26T22:30:21ZS-EPMC31824372197721210.3762/bjoc.7.148