{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["31(11)"],"submitter":["Werner A"],"journal":["The EMBO journal"],"pagination":["2439-40"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3365416"],"abstract":["Nucleocytoplasmic transport is an essential mechanism in all eukaryotic cells, for which the basic mechanisms seemed well understood. Transport receptors of the importin b/karyopherin family recognize, translocate and discharge cargo. Key to directed transport is the GTPase Ran, which determines compartment-specific interactions between receptors and their cargo. In this issue of The EMBO Journal, Rothenbusch et al (2012) now add a new energy-dependent event to this basic pathway by providing direct evidence that the posttranslational modification of the yeast import receptor Kap114 with small ubiquitin-related modifier (SUMO) is indispensable for its correct function. An exciting model emerges in which Kap114 sumoylation regulates Ran-dependent cargo release, and thereby acts as a mechanism for intranuclear targeting of the import cargo."],"repository":["biostudies-other"],"data_source":["Europe PMC"],"pubmed_authors":["Werner A","Melchior F"],"additional_accession":[]},"is_claimable":false,"name":"SUMO unloads the Kap114 cab.","description":"Nucleocytoplasmic transport is an essential mechanism in all eukaryotic cells, for which the basic mechanisms seemed well understood. Transport receptors of the importin b/karyopherin family recognize, translocate and discharge cargo. Key to directed transport is the GTPase Ran, which determines compartment-specific interactions between receptors and their cargo. In this issue of The EMBO Journal, Rothenbusch et al (2012) now add a new energy-dependent event to this basic pathway by providing direct evidence that the posttranslational modification of the yeast import receptor Kap114 with small ubiquitin-related modifier (SUMO) is indispensable for its correct function. An exciting model emerges in which Kap114 sumoylation regulates Ran-dependent cargo release, and thereby acts as a mechanism for intranuclear targeting of the import cargo.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 May","modification":"2019-08-03T07:35:39Z","creation":"2019-08-03T07:35:39Z"},"accession":"S-EPMC3365416","cross_references":{"DOI":["10.1038/emboj.2012.103 "]}}