biostudies-otherUnknown11(5)Liu NMarine drugs1524-33https://www.ebi.ac.uk/biostudies/studies/S-EPMC3707159Two new oxazole/thiazole derivatives, named tetroazolemycins A (1) and B (2), have been isolated from the acetone extract of the mycelium of Streptomyces olivaceus FXJ8.012 derived from deep-sea water, together with three known compounds, spoxazomicins A-C (3-5), isolated from the fermentation supernatant. The planar structure and relative configuration of tetroazolemycins were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR techniques, and showed to be new pyochelin-type antibiotics. Both compounds showed metal ion-binding activity and their Zn²? complexes exhibited weak activity against pathogenic bacteria Klebsiella pneumoniae.biostudies-otherPMC3707159Europe PMCXi LHuang YLiu NShang FfalseTetroazolemycins A and B, two new oxazole-thiazole siderophores from deep-sea Streptomyces olivaceus FXJ8.012.Two new oxazole/thiazole derivatives, named tetroazolemycins A (1) and B (2), have been isolated from the acetone extract of the mycelium of Streptomyces olivaceus FXJ8.012 derived from deep-sea water, together with three known compounds, spoxazomicins A-C (3-5), isolated from the fermentation supernatant. The planar structure and relative configuration of tetroazolemycins were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR techniques, and showed to be new pyochelin-type antibiotics. Both compounds showed metal ion-binding activity and their Zn²? complexes exhibited weak activity against pathogenic bacteria Klebsiella pneumoniae.2013-01-01T00:00:00Z2013 May2019-03-27T01:12:46Z2019-03-27T01:12:46ZS-EPMC37071592366595810.3390/md11051524