biostudies-other00480Unknown3(10)Keith JMACS medicinal chemistry letters823-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC4025847A series of aryl piperazinyl ureas that act as covalent inhibitors of fatty acid amide hydrolase (FAAH) is described. A potent and selective (does not inhibit FAAH-2) member of this class, JNJ-40355003, was found to elevate the plasma levels of three fatty acid amides: anandamide, oleoyl ethanolamide, and palmitoyl ethanolamide, in the rat, dog, and cynomolgous monkey. The elevation of the levels of these lipids in the plasma of monkeys suggests that FAAH-2 may not play a significant role in regulating plasma levels of fatty acid ethanolamides in primates.biostudies-otherPMC4025847Europe PMCChang LWilson SWennerholm MScott BChaplan SPierce JXiao WWebb MRizzolio MKeith JMApodaca RSeierstad MTichenor MLuo LRynberg RBreitenbucher JGJones WPalmer JKarbarz MBrown S48falseAryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate.A series of aryl piperazinyl ureas that act as covalent inhibitors of fatty acid amide hydrolase (FAAH) is described. A potent and selective (does not inhibit FAAH-2) member of this class, JNJ-40355003, was found to elevate the plasma levels of three fatty acid amides: anandamide, oleoyl ethanolamide, and palmitoyl ethanolamide, in the rat, dog, and cynomolgous monkey. The elevation of the levels of these lipids in the plasma of monkeys suggests that FAAH-2 may not play a significant role in regulating plasma levels of fatty acid ethanolamides in primates.2012-01-01T00:00:00Z2012 Oct2019-03-27T01:28:29Z2019-03-27T01:28:29ZS-EPMC40258472490038510.1021/ml300186g 2wap