{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(8)"],"submitter":["Kobayashi T"],"journal":["ACS medicinal chemistry letters"],"pagination":["889-93"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4137383"],"abstract":["On the basis of the three-dimensional diversity-oriented conformational restriction strategy using key chiral cyclopropane units, we previously identified 3 ((2S,3R)-4-amino-3,4-methanobutyric acid) with a chiral trans-cyclopropane structure as a ?-aminobutyric acid (GABA) transporter inhibitor selective for GABA transporter (GAT) subtypes GAT-3 and BGT-1 (betaine/GABA transporter-1). Further conformational restriction of 3 with the rigid bicyclo[3.1.0]hexane backbone led to the successful development of the first highly potent and selective BGT-1 inhibitor 4 (IC50 = 0.59 ?M). The bioactive conformation of 3 for BGT-1 was also identified."],"repository":["biostudies-other"],"pmcid":["PMC4137383"],"data_source":["Europe PMC"],"pubmed_authors":["Igawa A","Kobayashi T","Shuto S","Suemasa A","Arisawa M","Ide S","Abe H","Fukuda H","Minami M"],"additional_accession":[]},"is_claimable":false,"name":"Conformationally Restricted GABA with Bicyclo[3.1.0]hexane Backbone as the First Highly Selective BGT-1 Inhibitor.","description":"On the basis of the three-dimensional diversity-oriented conformational restriction strategy using key chiral cyclopropane units, we previously identified 3 ((2S,3R)-4-amino-3,4-methanobutyric acid) with a chiral trans-cyclopropane structure as a ?-aminobutyric acid (GABA) transporter inhibitor selective for GABA transporter (GAT) subtypes GAT-3 and BGT-1 (betaine/GABA transporter-1). Further conformational restriction of 3 with the rigid bicyclo[3.1.0]hexane backbone led to the successful development of the first highly potent and selective BGT-1 inhibitor 4 (IC50 = 0.59 ?M). The bioactive conformation of 3 for BGT-1 was also identified.","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Aug","modification":"2019-03-27T01:34:20Z","creation":"2019-03-27T01:34:20Z"},"accession":"S-EPMC4137383","cross_references":{"pubmed":["25147609"],"doi":["10.1021/ml500134k "]}}