{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"submitter":["Bossy B"],"funding":["NINDS NIH HHS"],"pagination":["2375-85"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC452932"],"abstract":["In this article, we describe the primary structure, the biochemical characterization and the tissue distribution of a novel integrin alpha subunit, named alpha 8. This subunit associates with the integrin beta 1 subunit to form alpha 8 beta 1 heterodimers. By sequence analysis, alpha 8 is more closely related to the alpha 5 and alpha v subunits than to other characterized integrin alpha subunits, but is clearly distinct from each of these. The alpha 8 subunit is expressed at moderate levels in several epithelial cells where its localization adjacent to basal laminae suggests that alpha 8-containing heterodimers interact with at least one extracellular matrix constituent. In embryos, the highest levels of alpha 8 protein expression are seen in the nervous system where alpha 8 is strongly expressed by several classes of projection neurons. The alpha 8 subunit is concentrated in axon tracts, including major projections in the spinal cord, optic system and auditory system. This tissue specific expression and cellular localization suggest that alpha 8-containing integrin receptors might promote axon outgrowth in the embryonic nervous system."],"repository":["biostudies-other"],"data_source":["Europe PMC"],"omics_type":["Unknown"],"volume":["10(9)"],"journal":["The EMBO journal"],"pmcid":["PMC452932"],"funding_grant_id":["NS21824"],"pubmed_authors":["Bossy B","Reichardt LF","Bossy-Wetzel E"],"additional_accession":[]},"is_claimable":false,"name":"Characterization of the integrin alpha 8 subunit: a new integrin beta 1-associated subunit, which is prominently expressed on axons and on cells in contact with basal laminae in chick embryos.","description":"In this article, we describe the primary structure, the biochemical characterization and the tissue distribution of a novel integrin alpha subunit, named alpha 8. This subunit associates with the integrin beta 1 subunit to form alpha 8 beta 1 heterodimers. By sequence analysis, alpha 8 is more closely related to the alpha 5 and alpha v subunits than to other characterized integrin alpha subunits, but is clearly distinct from each of these. The alpha 8 subunit is expressed at moderate levels in several epithelial cells where its localization adjacent to basal laminae suggests that alpha 8-containing heterodimers interact with at least one extracellular matrix constituent. In embryos, the highest levels of alpha 8 protein expression are seen in the nervous system where alpha 8 is strongly expressed by several classes of projection neurons. The alpha 8 subunit is concentrated in axon tracts, including major projections in the spinal cord, optic system and auditory system. This tissue specific expression and cellular localization suggest that alpha 8-containing integrin receptors might promote axon outgrowth in the embryonic nervous system.","dates":{"release":"1991-01-01T00:00:00Z","publication":"1991 Sep","modification":"2019-03-27T00:50:36Z","creation":"2019-03-27T00:50:36Z"},"accession":"S-EPMC452932","cross_references":{"gen":["X58519"],"pubmed":["1714374"]}}