{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"submitter":["Patil PC"],"funding":["NIDCR NIH HHS"],"pagination":["757-759"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4790446"],"abstract":["2-(Halomethyl)-4,5-diphenyloxazoles are effective, reactive scaffolds which can be utilized for synthetic elaboration at the 2-position. Through substitution reactions, the chloromethyl analogue is used to prepare a number of 2-alkylamino-, 2-alkylthio- and 2-alkoxy-(methyl) oxazoles. The 2-bromomethyl analogue offers a more reactive alternative to the chloromethyl compounds and is useful in the C-alkylation of a stabilized (malonate) carbanion as exemplified by a concise synthesis of Oxaprozin."],"repository":["biostudies-other"],"data_source":["Europe PMC"],"omics_type":["Unknown"],"volume":["57(7)"],"journal":["Tetrahedron letters"],"pmcid":["PMC4790446"],"funding_grant_id":["R01 DE023206"],"pubmed_authors":["Luzzio FA","Patil PC"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of extended oxazoles II: Reaction manifold of 2-(halomethyl)-4,5-diaryloxazoles.","description":"2-(Halomethyl)-4,5-diphenyloxazoles are effective, reactive scaffolds which can be utilized for synthetic elaboration at the 2-position. Through substitution reactions, the chloromethyl analogue is used to prepare a number of 2-alkylamino-, 2-alkylthio- and 2-alkoxy-(methyl) oxazoles. The 2-bromomethyl analogue offers a more reactive alternative to the chloromethyl compounds and is useful in the C-alkylation of a stabilized (malonate) carbanion as exemplified by a concise synthesis of Oxaprozin.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Feb","modification":"2019-03-27T02:11:02Z","creation":"2019-03-27T02:11:02Z"},"accession":"S-EPMC4790446","cross_references":{"pubmed":["26989270"],"doi":["10.1016/j.tetlet.2016.01.016 "]}}