{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"submitter":["Brockway AJ"],"funding":["NIAID NIH HHS"],"pagination":["2065-2068"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4966539"],"abstract":["An improved synthesis of MDL 73811 - a potent AdoMetDC (S-adenosylmethionine decarboxylease) inhibitor and anti-trypanosomal compound with in vivo activity has been completed in four steps from commercially available 2',3'-O-isopropylideneadenosine. Utilization of Mitsunobu chemistry was crucial for the reliable and scalable introduction of the 5'-methylamine moiety, which was problematic using traditional activation/displacement chemistry as previously reported. All reactions in this synthesis were run on gram-scale resulting in a five-fold increase in yield over the original synthesis."],"repository":["biostudies-other"],"data_source":["Europe PMC"],"omics_type":["Unknown"],"volume":["48(13)"],"journal":["Synthesis"],"pmcid":["PMC4966539"],"funding_grant_id":["R01 AI090599"],"pubmed_authors":["Phillips MA","Brockway AJ","De Brabander JK","Volkov OA","Cosner CC"],"additional_accession":[]},"is_claimable":false,"name":"Improved Synthesis of MDL 73811 - a Potent AdoMetDC Inhibitor and Anti-Trypanosomal Compound.","description":"An improved synthesis of MDL 73811 - a potent AdoMetDC (S-adenosylmethionine decarboxylease) inhibitor and anti-trypanosomal compound with in vivo activity has been completed in four steps from commercially available 2',3'-O-isopropylideneadenosine. Utilization of Mitsunobu chemistry was crucial for the reliable and scalable introduction of the 5'-methylamine moiety, which was problematic using traditional activation/displacement chemistry as previously reported. All reactions in this synthesis were run on gram-scale resulting in a five-fold increase in yield over the original synthesis.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jul","modification":"2019-03-27T02:19:29Z","creation":"2019-03-27T02:19:29Z"},"accession":"S-EPMC4966539","cross_references":{"pubmed":["27482123"],"doi":["10.1055/s-0035-1561608 "]}}