{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(6)"],"submitter":["Dalby MJ"],"journal":["Cell reports"],"pagination":["1521-1533"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5695904"],"abstract":["Evidence suggests that altered gut microbiota composition may be involved in the development of obesity. Studies using mice made obese with refined high-fat diets have supported this; however, these have commonly used chow as a control diet, introducing confounding factors from differences in dietary composition that have a key role in shaping microbiota composition. We compared the effects of feeding a refined high-fat diet with those of feeding either a refined low-fat diet or a chow diet on gut microbiota composition and host physiology. Feeding both refined low- or high-fat diets resulted in large alterations in the gut microbiota composition, intestinal fermentation, and gut morphology, compared to a chow diet. However, body weight, body fat, and glucose intolerance only increased in mice fed the refined high-fat diet. The choice of control diet can dissociate broad changes in microbiota composition from obesity, raising questions about the previously proposed relationship between gut microbiota and obesity."],"repository":["biostudies-other"],"pmcid":["PMC5695904"],"data_source":["Europe PMC"],"pubmed_authors":["Dalby MJ","Ross AW","Morgan PJ","Walker AW"],"additional_accession":[]},"is_claimable":false,"name":"Dietary Uncoupling of Gut Microbiota and Energy Harvesting from Obesity and Glucose Tolerance in Mice.","description":"Evidence suggests that altered gut microbiota composition may be involved in the development of obesity. Studies using mice made obese with refined high-fat diets have supported this; however, these have commonly used chow as a control diet, introducing confounding factors from differences in dietary composition that have a key role in shaping microbiota composition. We compared the effects of feeding a refined high-fat diet with those of feeding either a refined low-fat diet or a chow diet on gut microbiota composition and host physiology. Feeding both refined low- or high-fat diets resulted in large alterations in the gut microbiota composition, intestinal fermentation, and gut morphology, compared to a chow diet. However, body weight, body fat, and glucose intolerance only increased in mice fed the refined high-fat diet. The choice of control diet can dissociate broad changes in microbiota composition from obesity, raising questions about the previously proposed relationship between gut microbiota and obesity.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Nov","modification":"2019-03-27T03:02:30Z","creation":"2019-03-27T03:02:30Z"},"accession":"S-EPMC5695904","cross_references":{"pubmed":["29117558"],"doi":["10.1016/j.celrep.2017.10.056 "]}}