{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Dr. Marco Gaviraghi"],"funding":["Associazione Italiana per la Ricerca sul Cancro (AIRC)","Ministero della Salute (Ministry of Health, Italy)"],"journal":["The EMBO Journal"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-SCDT-EMBOJ-2018-99179"],"abstract":["Focal deletions occur frequently in the cancer genome. However, the putative tumor suppressive genes residing within these regions have been difficult to pinpoint. To robustly identify these genes, we implemented a computational approach based on Non-negative Matrix Factorization, NMF and interrogated the TCGA dataset. This analysis revealed a metagene signature including a small subset of genes showing pervasive hemizygous deletions, reduced expression in cancer patient samples and nucleolar function. Amid the genes belonging to this signature, we have identified PNRC1, a nuclear receptor coactivator. We found that PNRC1 interacts with the cytoplasmic DCP1?/DCP2 decapping machinery and hauls it inside the nucleolus. PNRC1-dependent nucleolar translocation of the decapping complex is assoc"],"repository":["biostudies-other"],"pubmed_authors":["Dr. Francesca Invernizzi","Dr. Marco Gaviraghi","Dr. Vicent Pelechano","Dr. Claudia Vivori","Angela Cattaneo","Claudio Doglioni","Dr. Giovanni Tonon","Davide Cittaro","Dr. Michela Frenquelli","Dr. Simona Segalla","Angela Bachi","Dr. Yerma, P Sanchez","Dr. Benedetta, M Santoliquido"],"additional_accession":[]},"is_claimable":false,"name":"TUMOR SUPPRESSOR PNRC1 BLOCKS rRNA MATURATION BY RECRUITING THE DECAPPING COMPLEX TO THE NUCLEOLUS","description":"Focal deletions occur frequently in the cancer genome. However, the putative tumor suppressive genes residing within these regions have been difficult to pinpoint. To robustly identify these genes, we implemented a computational approach based on Non-negative Matrix Factorization, NMF and interrogated the TCGA dataset. This analysis revealed a metagene signature including a small subset of genes showing pervasive hemizygous deletions, reduced expression in cancer patient samples and nucleolar function. Amid the genes belonging to this signature, we have identified PNRC1, a nuclear receptor coactivator. We found that PNRC1 interacts with the cytoplasmic DCP1?/DCP2 decapping machinery and hauls it inside the nucleolus. PNRC1-dependent nucleolar translocation of the decapping complex is assoc","dates":{"release":"2019-06-05T23:42:08Z","modification":"2019-06-05T23:42:08Z","creation":"2019-06-05T23:42:08Z"},"accession":"S-SCDT-EMBOJ-2018-99179","cross_references":{"doi":["10.15252/embj.201899179"]}}