{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Dr. Shingo Kajimura"],"funding":["HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","Edward Mallinckrodt, Jr. Foundation (EMF)","Japan Society for the Promotion of Science London (JSPS London)","Manpei Suzuki Diabetes Foundation"],"journal":["EMBO Reports"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-SCDT-EMBOR-2019-49828-T"],"abstract":["While brown adipose tissue (BAT) is well-recognized for its ability to dissipate energy in the form of heat, recent studies suggest multifaced roles of BAT in the regulation of glucose and lipid homeostasis beyond stimulating thermogenesis. One of the functions involves inter-organ communication with metabolic organs, such as the liver, through BAT-derived secretory factors, a.k.a., batokine. However, the identity and the roles of such mediators remain insufficiently understood. Here, we employed proteomics and transcriptomics in human thermogenic adipocytes and identified previously unappreciated batokines, including phospholipid transfer protein (PLTP). We found that increased circulating levels of PLTP, via systemic or BAT-specific overexpression, significantly improves glucose toleranc"],"repository":["biostudies-other"],"funding_grant_id":["DK108822","DK97441"],"pubmed_authors":["Makoto Takahashi","Takeshi Yoneshiro","Hiroshi Karasawa","Takashi Hosono","Rachana Pradhan","Yumi Matsui","Yoko Yokoyama","Dr. Kazuki Tajima","Carl, C. Ward","Hiroki Taoka","Kenji Ikeda","Zachary Brown","Carlos, H. Sponton","Dr. Shingo Kajimura","Junki Taura","Lindsay, S. Roberts","Mitsuhiro Watanabe","Dr. Daniel Nomura","Kosaku Shinoda","Dr. Yasuo Oguri","Mark, P. Jedrychowski","Qiang Wang","Yong Chen"],"additional_accession":[]},"is_claimable":false,"name":"The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT-liver communication","description":"While brown adipose tissue (BAT) is well-recognized for its ability to dissipate energy in the form of heat, recent studies suggest multifaced roles of BAT in the regulation of glucose and lipid homeostasis beyond stimulating thermogenesis. One of the functions involves inter-organ communication with metabolic organs, such as the liver, through BAT-derived secretory factors, a.k.a., batokine. However, the identity and the roles of such mediators remain insufficiently understood. Here, we employed proteomics and transcriptomics in human thermogenic adipocytes and identified previously unappreciated batokines, including phospholipid transfer protein (PLTP). We found that increased circulating levels of PLTP, via systemic or BAT-specific overexpression, significantly improves glucose toleranc","dates":{"release":"2020-09-02T00:00:00Z","modification":"2020-09-02T17:09:11Z","creation":"2020-09-02T17:09:11Z"},"accession":"S-SCDT-EMBOR-2019-49828-T","cross_references":{"doi":["10.15252/embr.201949828"]}}