biostudies-otherUnknownGiuseppe AielloFondazione Umberto Veronesi (Umberto Veronesi Foundation)Fondazione Cassa Di Risparmio Di Trento E Rovereto (Caritro Foundation)Ministero dell'Istruzione, dell'Università e della Ricerca (MIUR)Giovanni Armenise-Harvard Foundation (GAHF)Associazione Italiana per la Ricerca sul Cancro (AIRC)EC | H2020 | H2020 Priority Excellent Science | H2020 Marie Skłodowska-Curie Actions (MSCA)Fondazione Pezcoller (Pezcoller Foundation)EMBO Reportshttps://www.ebi.ac.uk/biostudies/studies/S-SCDT-EMBOR-2022-55299V1Lifespan is determined by complex and tangled mechanisms that are largely unknown. The early postnatal stage has been proposed to play a role in lifespan, but its contribution is still controversial. Here, we show that a short rapamycin treatment during early life can prolong lifespan in Mus musculus and Drosophila melanogaster. Notably, the same treatment at later time points has no effect on lifespan, suggesting that a specific time-window is involved in lifespan regulation. We also find tha sulfotransferases are upregulated during early rapamycin treatment both in newborn mice and Drosophila larvae, and transient dST1 overexpression in Drosophila larvae extends lifespan [OK?]. Our findings unveil a novel link between early-life treatments and long-term effects on lifespan.biostudies-other2062120182016202184467719921Matteo AudanoProf. Alessandro QuattroneDr. Francesco AntonicaMr. Matteo GianeselloProf. Luca TiberiMr. Davide PerniciGiuseppe AielloDr. Claudio BallabioAlessandro RomanelMr. Cosimo SabinoNico MitroDr. Alessia SoldanofalseTransient rapamycin treatment during developmental stage extends lifespan in Mus musculus and Drosophila melanogasterLifespan is determined by complex and tangled mechanisms that are largely unknown. The early postnatal stage has been proposed to play a role in lifespan, but its contribution is still controversial. Here, we show that a short rapamycin treatment during early life can prolong lifespan in Mus musculus and Drosophila melanogaster. Notably, the same treatment at later time points has no effect on lifespan, suggesting that a specific time-window is involved in lifespan regulation. We also find tha sulfotransferases are upregulated during early rapamycin treatment both in newborn mice and Drosophila larvae, and transient dST1 overexpression in Drosophila larvae extends lifespan [OK?]. Our findings unveil a novel link between early-life treatments and long-term effects on lifespan.2022-08-03T00:00:00Z2022-08-03T20:00:35.564Z2022-08-03T20:00:35.564ZS-SCDT-EMBOR-2022-55299V110.15252/embr.202255299