biostudies-otherUnknownDr. Irem Bayindir-BuchhalterDeutsche Forschungsgemeinschaft (DFG)Novo NordiskHelmholtz International Graduate School for Cancer ResearchBrain Tumor NetworkHuman Frontier Science Program (HFSP)German Ministry of Education and ResearchEMBO Molecular Medicinehttps://www.ebi.ac.uk/biostudies/studies/S-SCDT-EMM-2017-08613Most antidiabetic drugs treat disease symptoms rather than adipose tissue dysfunction as a key pathogenic cause in the metabolic syndrome and type 2 diabetes. Pharmacological targeting of adipose tissue through the nuclear receptor PPARg, as exemplified by glitazone treatments, mediates efficacious insulin sensitization. However, a better understanding of the context-specific PPARg responses is required for the development of novel approaches with reduced side effects. Here we identified the transcriptional cofactor Cited4 as a target and mediator of rosiglitazone in human and murine adipocyte progenitor cells, where it promoted specific sets of the rosiglitazone-dependent transcriptional program. In mice, Cited4 was required for the proper induction of thermogenic expression by Rosi specibiostudies-otherInfrafrontier grant 01KX1012RGY0082/2014NGFNplus #01GS0883HE 3260/8-1Dr. Lars KetscherDr. Damir KrunicDr. Alexandros VegiopoulosProf. Mathias HeikenwälderDr. Jorge, Lira RuasDr. Adrian, T BilleterProf. Peter LichterDr. Irem Bayindir-BuchhalterDr. Rohollah BabaeiTjeerd SijmonsmaDr. Gretchen WolffDr. Jan GronychMrs. Sarah LerchDr. Nadine SpielmannProf. Martin Hrabě de AngelisMr. Maximilian SchusterProf. Beat, P Müller-StichProf. Stephan HerzigfalseCited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitorsMost antidiabetic drugs treat disease symptoms rather than adipose tissue dysfunction as a key pathogenic cause in the metabolic syndrome and type 2 diabetes. Pharmacological targeting of adipose tissue through the nuclear receptor PPARg, as exemplified by glitazone treatments, mediates efficacious insulin sensitization. However, a better understanding of the context-specific PPARg responses is required for the development of novel approaches with reduced side effects. Here we identified the transcriptional cofactor Cited4 as a target and mediator of rosiglitazone in human and murine adipocyte progenitor cells, where it promoted specific sets of the rosiglitazone-dependent transcriptional program. In mice, Cited4 was required for the proper induction of thermogenic expression by Rosi speci2018-12-05T16:19:33Z2018-12-05T16:19:33Z2018-12-04T11:03:02ZS-SCDT-EMM-2017-0861310.15252/emmm.201708613