{"database":"Cell Collective","file_versions":[],"scores":{"citationCount":10768,"reanalysisCount":0,"viewCount":0,"searchCount":0},"additional":{"omics_type":["Models"],"submitter":["Audrey Crowther"],"version_name":[""],"full_dataset_link":["https://cellcollective.org/#4705/septation-initiation-network"],"model_score":["29.900000000000002"],"default_version":["1"],"ModelFormat":["SBML"],"submitter_affiliation":[""],"submitter_email":[""],"version_id":["1"],"repository":["Cell Collective"],"version_url":["https://cellcollective.org/#4705:1/septation-initiation-network"],"version_description":[""],"pubmed_abstract":["Cytokinesis in fission yeast is controlled by the Septation Initiation Network (SIN), a protein kinase signaling network using the spindle pole body as scaffold. In order to describe the qualitative behavior of the system and predict unknown mutant behaviors we decided to adopt a Boolean modeling approach. In this paper, we report the construction of an extended, Boolean model of the SIN, comprising most SIN components and regulators as individual, experimentally testable nodes. The model uses CDK activity levels as control nodes for the simulation of SIN related events in different stages of the cell cycle. The model was optimized using single knock-out experiments of known phenotypic effect as a training set, and was able to correctly predict a double knock-out test set. Moreover, the model has made in silico predictions that have been validated in vivo, providing new insights into the regulation and hierarchical organization of the SIN."],"pubmed_title":["An Extended, Boolean Model of the Septation Initiation Network in S.Pombe Provides Insights into Its Regulation."],"pubmed_authors":["Chasapi Anastasia A, Wachowicz Paulina P, Niknejad Anne A, Collin Philippe P, Krapp Andrea A, Cano Elena E, Simanis Viesturs V, Xenarios Ioannis I"],"description_synonyms":["EFS2, CAS3, Regulations, EFS1., septation initiation network, Controlling, cyclin D-cdk6 kinase activity, preventive therapy, CDK, Formal Social Control, neuronal cdc2-like kinase activity, Fission, D-type cyclin kinase activity, catalytic subunit activity, Schizosaccharomyces pombe, Schizosaccharomyces malidevorans, S pombe, Divisions, Cell, prevention, Division Cycles, Social Controls, Cytokineses, Cdk-activating protein kinase activity, septation initiation signalling, cdk-activating kinase activity, Fission Yeast, Social Control, HEFS, Cytoplasmic Division, Cycle, septation initiation signaling, RPC5, cyclin-A associated kinase activity, SIN, Sin, intrinsic catalyst activity, prevention and control, fission yeast, cyclin-dependent kinase-2 activity, Formal Social Controls, EFS1, cyclin-dependent protein kinase, Cell Division Cycles, Cycles, septation initiation signaling cascade, Yeast, Schizosaccharomyces pombeP, cyclin-dependent kinase activity, cell cycle cytokinesis, reference sample, Division Cycle, cdc2 kinase activity, prophylaxis, cyclin E kinase activity, cyclin-dependent protein kinase activity, Cell Division Cycle, ATP:cyclin phosphotransferase activity, cell-division cycle, Control, Cell Division, sil, Controls, Division, cyclin D-dependent kinase activity, Cytoplasmic, Social, preventive measures, cyclin-dependent kinase-4 activity, cyclin-dependent kinase 6 activity, Fission Yeasts, cytokinesis involved in cell cycle, ATP - cyclin phosphotransferase activity, control, Cell Cycles, Cytoplasmic Divisions, regulation, Regulation, CASS3, CDK activity, Controlled"],"pubmed_title_synonyms":["Social, Regulations, septation initiation signaling cascade, septation initiation signalling, septation initiation network, Social Control, Social Controls., Formal Social Control, septation initiation signaling, Control, regulation, SIN, Controls, Regulation, Formal Social Controls"],"name_synonyms":["septation initiation signaling, SIN., septation initiation signaling cascade, septation initiation signalling, septation initiation network"],"pubmed_abstract_synonyms":["CAS3, Regulations, septation initiation network, IPP2A2, cyclin D-cdk6 kinase activity, Bodies, CDK, Processes, neuronal cdc2-like kinase activity, Fission, catalytic subunit activity, organization and administration, Non-Governmental Organizations, Progress Reports, Schizosaccharomyces pombe, Schizosaccharomyces malidevorans, Spindle Pole, Divisions, prevention, PHAPII, Social Controls, Cytokineses, 5730420M11Rik, septation initiation signalling, Fission Yeast, Investigative, Summary Report, Cycle, Non-Governmental, Kinase, RPC5, prevention and control, fission yeast, Summary Reports, Formal Social Controls, cyclin-dependent protein kinase, Cell Division Cycles, Cycles, SET, Organization, Schizosaccharomyces pombeP, anatomical systems, reference sample, Progress Report, teaching, TAF-I, cyclin E kinase activity, cyclin-dependent protein kinase activity, ipp2a2, Cell Division Cycle, cell-division cycle, 2pp2a, Cell Division, Division, ATP-protein phosphotransferase, CG10574, Cytoplasmic, DmelCG4299, Social, preventive measures, Progress, cyclin-dependent kinase-4 activity, IGAAD, set, cytokinesis involved in cell cycle, SNRK2-2, Field Reports, 2PP2A, Non-Governmental Organization, ATP - cyclin phosphotransferase activity, DmelCG10574, taf-ibeta, curriculum, Cell Cycles, dSET, dSet, Organizations, organization, Behaviors, Investigative Reports, CASS3, Controlled, single organism signaling, Spindle Pole Body, single-organism behavior, EFS2, phapii, EFS1., Controlling, SPB, preventive therapy, Papers, organisation, Process, Formal Social Control, organizational structure, igaad, D-type cyclin kinase activity, StF-IT-1, S pombe, Cell, Acceptance Processes, Division Cycles, group, Cdk-activating protein kinase activity, Acceptance Process, SRK2D, cdk-activating kinase activity, Investigative Report, I-2PP2A, Social Control, HEFS, Cytoplasmic Division, Protein, Research Reports, Dm I-2, I2PP2A, septation initiation signaling, cyclin-A associated kinase activity, SIN, Sin, intrinsic catalyst activity, Nongovernmental Organizations, cyclin-dependent kinase-2 activity, EFS1, administrative management, Acceptance, Yeast, septation initiation signaling cascade, cyclin-dependent kinase activity, cell cycle cytokinesis, SPK-2-2, HLA-DR-associated protein II, Division Cycle, training, ensemble, DI-2, Kinases, cdc2 kinase activity, Nongovernmental, prophylaxis, I-2Dm, administrative structure, Field, ATP:cyclin phosphotransferase activity, Control, sil, CG4299, Controls, Body, cyclin D-dependent kinase activity, I-2PP1, cyclin-dependent kinase 6 activity, dSET/TAF-Ibeta, SNF1-RELATED PROTEIN KINASE 2-2, Fission Yeasts, Report, 2610030F17Rik, Non Governmental Organizations, TAF-IBETA, signalling process, Reports, SNF1-related protein kinase 2.2, control, Cytoplasmic Divisions, organizational management, TAF-Ibeta, regulation, Summary, AA407739, PROTEIN KINASE, Protein Kinase, i2pp2a, Regulation, Nongovernmental Organization, Field Report, CDK activity"],"citation_count":["10768"],"additional_accession":[]},"is_claimable":false,"name":"Septation Initiation Network","description":"The Septation Initiation Network (SIN) controls cytokinesis in fission yeast. This model uses CDK activity levels as control nodes to simutate SIN related events throughout different stages of the cell cycle. This model was optimized using single knock-out experiments and has made in silico predictions that have been validated in vivo, offering new insights into regulation of the SIN. ","dates":{"created":"2016-07-21","publication":"","submission":"2017-02-06","last_modified":"2017-02-06"},"accession":"4705","cross_references":{"pubmed":["26244885"]}}