Cell Collective0000ModelsRaphaelle LesageProtein signalling networkhttps://cellcollective.org/#49566/virtual-chondrocyte--ppi-layer26.11SBML1Cell Collectivehttps://cellcollective.org/#49566:1/virtual-chondrocyte--ppi-layerPart 1/2: Protein signalling pathways. (See model 'Gene regulatory network' for part 2/2)Chondrocyte, 0998/12, biological signaling, Articular Cartilage, nucleocytoplasm, Materials, Arthritides, PNT-P1, ETS2, Ets2, DmelCG17077, Cartilage, Gene, EY3-1, Pnt, protein, protein-containing complex, dermarticulare, Normalcies, composed of, Transcription Factor, epiphyseal disk, Growth Factors, DMPOINT1A, pntegfr, 0608/07, png, osteoarthrosis and allied disorder, Osteoarthritides, Growth Plates, Gene Products, Paracrine Protein Factors, Growth Factor, D-ets-2, 3520, protein aggregate, Cartilages, Osteoarthroses, Osteoarthritis, degenerative arthritis, Chondroblast, Pnt-P1, protoplasm, Normalities, average, cartilage cell, Transcription, Growth, FOCUS, Genetic, protoplast, pointed-RC, Arthritis, composition, goniale, EK3-2, Peptide Factors, l(3)07825, degenerative joint disease, angulare, Degenerative polyarthritis, Epiphyseal, signaling process, Degenerative joint disease, Plate, Articular Cartilages, Hypertrophic arthritis, operculo angulaire, CG17077, Arthroses, cartilago epiphysialis, Paracrine, l(3)j1B7, single organism signaling, hyaline cartilage, signalling., Individual Health, Ets, protein complex, Proteins, D-Ets-2, Epiphyseal Plate, ets94F, 0123/09, Factor, Normalcy, compositionality, Cistrons, Epiphyseal Cartilage, Plates, Osteoarthrosis Deformans, native protein, joint-associated cartilage, physis, Protein, Genetic Materials, Individual, internal to cell, Osteoarthrosis, pnt-P1, pnt-P2, l(3)s118306, Genetic Material, Paracrine Peptide Factors, pntP2, epiphyseal growth disk, Factors, Pointed-P1, Normality, content, Degenerative Arthritides, osteoarthrosis, Ets94F, epiphyseal cartilage, INSDC_feature:gene, hypertrophic arthritis, angulaire, signalling, Protein Gene Products, ptd, Gene Proteins, PntP2, Chondroblasts, Health, Ets58AB, signalling process, Degenerative, Articular, Material, Epiphyseal Cartilages, PntP1, E(E2F)3D, structure, Arthrosis, Cistron, PNTP2, Degenerative Joint Disease, Degenerative Arthritis, PNTP1, growth plate, POINT, Epiphyseal Plates, degenerative, CG8705layer of cells, lamina, cartilage cell, Chondrocyte, Chondroblasts, cell sheath, PPI, sheath of cells., layer, Chondroblast0falseVirtual chondrocyte - PPI layerComprehensive intracellular regulatory network of articular chondrocyte in health and osteoarthritis. The focus is on articular cartilage and osteoarthritis: growth plate network was used as a starting point and was extended to articular cartilage chondrocyte. The full regulatory network is composed of 2 subnetworkss: (1) the protein signalling pathways (from growth factors to the transcription factors) and (2) the gene regulatory network (transcription factors regulating the gene that code for the upstream proteins). This version corresponds to the part (1) protein signalling network.2019-02-052022-10-032022-10-034956610.1101/2021.09.27.461207