Cell Collective154000ModelsRobert Moore1https://cellcollective.org/#91515/immune-system-model0.11SBML1Cell Collectivehttps://cellcollective.org/#91515:1/immune-system-model<h4>Background</h4>Despite decades of new discoveries in biomedical research, the overwhelming complexity of cells has been a significant barrier to a fundamental understanding of how cells work as a whole. As such, the holistic study of biochemical pathways requires computer modeling. Due to the complexity of cells, it is not feasible for one person or group to model the cell in its entirety.<h4>Results</h4>The Cell Collective is a platform that allows the world-wide scientific community to create these models collectively. Its interface enables users to build and use models without specifying any mathematical equations or computer code - addressing one of the major hurdles with computational research. In addition, this platform allows scientists to simulate and analyze the models in real-time on the web, including the ability to simulate loss/gain of function and test what-if scenarios in real time.<h4>Conclusions</h4>The Cell Collective is a web-based platform that enables laboratory scientists from across the globe to collaboratively build large-scale models of various biological processes, and simulate/analyze them in real time. In this manuscript, we show examples of its application to a large-scale model of signal transduction.The Cell Collective: toward an open and collaborative approach to systems biology.Helikar Tomáš T, Kowal Bryan B, McClenathan Sean S, Bruckner Mitchell M, Rowley Thaine T, Madrahimov Alex A, Wicks Ben B, Shrestha Manish M, Limbu Kahani K, Rogers Jim A JATaf[[II]]250, Taf200, dTAF[[II]]230, TAF[[II]]250, d230, dTAF[[II]]250, TAF[[II]]230, TFIID TAF250, Collective, Systems., Biology, cel, cell, TAF200, l(3)84Ab, dTAFII250, Taf1p, TAF[II]250, BG:DS00004.13, TAFII-250, CG17603, TAF250/230, TAF[[II]], EfW1, Cell, dTAF230, dTAF250, dmTAF[[II]]230, TAFII250, DmelCG17603, Taf250, dmTAF1, SR3-5, Taf230, p230, TAF[[II]]250/230, TFIID, TAF, TAF230, TAF250, TAF1Immune, Immune., Immune Systems, System, SystemsSignal Transduction Systems, scale tissue, Signal Transductions, d230, Activity, Laboratory, Effects, acetylglucosaminyltransferase-like protein, P62, Programmable, peltate hair, Receptor-Mediated, Mbp1, dTAFII250, Signal Transduction System, sci, Computer, broad, EfW1, LARGE1, Long Term, froggy, Biomedical, Gyltl1a, protrusion, Calculators, dmTAF[[II]]230, Receptor Mediated Signal Transduction, Readability, Signal Transduction, Investigative, dmTAF1, Taf230, Medical Research, eye, HOW, How, globe, Research Activity, Cell Signaling, myd, Medical, Laboratory Research, Effect, l(3)j5D5, Person, TAF250, 24B, Priorities, signal transduction by protein phosphorylation, study, Taf200, dTAF[[II]]250, l(3)s2612, TFIID TAF250, like-acetylglucosaminyltransferase, Research, cel, Longterm, cell, MDDGB6, plant peltate hair, stru, Signal, Mbp-1, Pathways, Taf1p, LARGE, l(3)S053606, Signal Pathways, Long-Term, CG10293, Signal Transduction Pathway, l(3)j5B5, dTAF250, BPFD#36, set, signalling pathway, grupos, DmelCG10293, Investigational Medicine, Medicine, signal transduction by cis-phosphorylation, Long-Term Effect, Signal Transduction Pathways, Development and Research, Transductions, Research Priority, TAF, Long-Term Effects, eye globe, 0904/17, dTAF[[II]]230, TAF[[II]]250, Pathway, anatomical protrusion, grupo, wide/broad, Collective, gyltl1b-b, clone 2.39, TAF200, Longterm Effect, signal transduction by conformational transition, Digital Computers, Receptor-Mediated Signal Transductions, l(3)84Ab, Research Priorities, bulbus oculi, Computer Hardware, BG:DS00004.13, function, qkr, TAFII-250, TAF250/230, l(3)S090417, Cell, results, signal transduction by trans-phosphorylation, group, dTAF230, Investigative Medicine, signaling cascade, TAFII250, Experimental, Priority, SZ1, p230, MDDGA6, Receptor-Mediated Signal Transduction, KH93F, mKIAA0609, Long Term Effects, Systems, Research Activities, TAF[[II]]250/230, TFIID, laboratory, background, scales, signalling cascade, KIAA0609, Transduction, Investigational, acetylglucosaminyltransferase-like 1A, eyeball, who, Computers, Research and Development, Taf[[II]]250, fg, TAF[[II]]230, gyltl1b, Digital, scale, ensemble, Programmable Calculators, System, Experimental Medicine, mdc1d, Rest, TAF[II]250, Who/How, Calculator, Understanding, Hardware, CG17603, TAF[[II]], LARGE_HUMAN, introduction, Longterm Effects, Activities, MDC1D, wide, DmelCG17603, Digital Computer, like-glycosyltransferase, enr, signaling pathway, Taf250, spine, Signal Pathway., SR3-5, Manuscripts, qkr[93F], anon-EST:Liang-2.39, Programmable Calculator, groupe, TAF230, Gruppe, glycosyltransferase-like protein LARGE1, TAF1154falseImmune System Model2020-02-062020-03-122020-03-129151522871178