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ftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000394/phs000394.v1.p1/manifest/manifest_phs000394.CIDR_AutopsyPD.v1.p1.c1.ARU.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000394/phs000394.v1.p1/release_notes/Release_Notes.phs000394.CIDR_AutopsyPD.v1.p1.MULTI.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000394/phs000394.v1.p1/manifest/Study_Report.phs000394.CIDR_AutopsyPD.v1.p1.MULTI.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000394/phs000394.v1.p1/pheno_variable_summaries/phs000394.v1.pht002651.v1.APDGC_Subject.data_dict.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000394/phs000394.v1.p1/pheno_variable_summaries/phs000394.v1.pht002652.v1.APDGC_Sample.data_dict.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000394/phs000394.v1.p1/pheno_variable_summaries/phs000394.v1.pht002652.v1.p1.APDGC_Sample.var_report.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000394/phs000394.v1.p1/pheno_variable_summaries/phs000394.v1.pht002654.v1.p1.APDGC_Sample_Attributes.var_report.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000394/phs000394.v1.p1/GapExchange_phs000394.v1.p1.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000394/phs000394.v1.p1/pheno_variable_summaries/phs000394.v1.pht002653.v1.p1.APDGC_Subject_Phenotypes.var_report.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000394/phs000394.v1.p1/pheno_variable_summaries/phs000394.v1.pht002654.v1.APDGC_Sample_Attributes.data_dict.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000394/phs000394.v1.p1/pheno_variable_summaries/phs000394.v1.pht002653.v1.APDGC_Subject_Phenotypes.data_dict.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000394/phs000394.v1.p1/pheno_variable_summaries/phs000394.v1.pht002651.v1.p1.APDGC_Subject.var_report.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000394/phs000394.v1.p1/dbGaPEx2.1.5.xsdftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000394/phs000394.v1.p1/pheno_variable_summaries/varreports_v3.xslftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000394/phs000394.v1.p1/pheno_variable_summaries/datadict_v2.xslprimaryOK200GenomicCase-ControlParkinson's syndrome, Parkinsons, Parkinson's disease, Postmortem Examination, Primary Parkinsonism, Parkinsons disease, Parkinson disease, Post-Mortem Examinations, Parkinson's disease (disorder), Parkinson's disease NOS, Lewy Body, PARK, PARKINSON DIS, Paralysis agitans, Primary, IDIOPATHIC PARKINSONS DIS, PARKINSON DIS IDIOPATHIC, Post-Mortem, IDIOPATHIC PARKINSON DIS, Idiopathic PD, Examination, Idiopathic Parkinson Disease, Lewy Body Parkinson's Disease, LEWY BODY PARKINSON DIS, Parkinsonian disorder, Parkinson's, Autopsies, Idiopathic Parkinson's Disease, Postmortem, Idiopathic, Parkinson's disease NOS (disorder), Paralysis Agitans, paralysis agitans, Parkinson's Disease, Lewy Body Parkinson Disease, Examinations, PARKINSONS DIS IDIOPATHIC, Parkinson Disease, Parkinsonism, PARKINSONS DIS, Parkinson syndrome, PD, Post Mortem Examination, PARKINSONS DIS LEWY BODY., Postmortem Examinations, Post-Mortem Examinationhttp://www.udall.med.miami.edu/https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000394MINIMAL CLINICAL CRITERIA - PD Cases <ol> <li>There must be an antemortem CLINICAL DIAGNOSIS OF PARKINSONISM. Ideally the cases would have been considered to have idiopathic Parkinson's disease, but given the imprecision of clinical diagnoses, if the case meets pathologic exclusion and inclusion criteria (see below), but was misdiagnosed as an atypical parkinsonian disorder, such as progressive supranuclear palsy or multiple system atrophy, such cases are acceptable.</li> <li>There must not have been a prominent dementia syndrome, particularly dementia occurring at the time of onset or within one year of parkinsonism. Given the prevalence of some degree of cognitive impairment in idiopathic Parkinson's disease (as much as 80% in some series), cases with later developing cognitive problems can be included, but they must meet all the pathologic inclusion criteria.</li> </ol> PATHOLOGICAL EXCLUSION CRITERIA: There must be no other pathology that could reasonably be considered to be the structural substrate of parkinsonism. Excluded are cases with progressive supranuclear palsy, corticobasal degeneration, multiple system atrophy, frontotemporal degenerations and other disorders that can be associated with parkinsonism (e.g., normal pressure hydrocephalus, post-encephalitic parkinsonism, certain spinocerebellar atrophies or transmissible spongiform encephalopathies), even if they meet the minimal pathologic inclusion criteria. In other words, co-incidental Lewy bodies are not acceptable if they occur in an individual with another major pathologic process that could account for parkinsonism. Given that the age of many individuals to be included in the study is advanced, it is acceptable to have some age-related pathologies, such as cerebrovascular disease or argyrophilic grains. MINIMAL PATHOLOGICAL INCLUSION CRITERIA: <ol> <li>There must be moderate-to-severe substantia nigra neuronal loss.</li> <li>There must be Lewy bodies. Ideally, Lewy bodies will have been assessed with a sensitive method for their detection, such as immunohistochemistry for α-synuclein or ubiquitin, but if Lewy bodies were readily detected with routine histological methods, such as hematoxylin and eosin stains, the case meets minimum criteria for presence of Lewy bodies.</li> <li> There must be minimal Alzheimer type pathology. In an effort to exclude genetic factors that associate with Alzheimer's disease, only cases in which Alzheimer type pathology has been evaluated and only those that meet criteria 3a and 3b are acceptable. <ol type="a"> <li>Neuritic plaques must be no more than sparse in the neocortex. Neuritic plaques are defined according to the CERAD criteria, which requires assessment with either an appropriate silver stain or thioflavin S fluorescent microscopy. This criterion does not exclude cases with diffuse, non-neuritic plaques, which may be frequent, as long as the case also meets criterion 3b.</li> <li>Neurofibrillary tangle stage must be no more than Stage IV.</li> </ol> </li> </ol> MINIMAL CLINICAL CRITERIA - CONTROLS There must be NO antemortem clinical diagnosis of parkinsonism. PATHOLOGICAL CRITERIA: <ol> <li>There must be NO OR MILD substantia nigra neuronal loss.</li> <li>There must be NO LEWY BODIES in all brain regions examined. Given the uncertainty of Lewy bodies as a biomarker for PD and wishing not to dilute the power of genetic association, presence of Lewy bodies in any region, including olfactory bulb, autonomic nervous system and the amygdala is an exclusion criterion.</li> <li> There must be minimal Alzheimer type pathology. In an effort to exclude genetic factors that associate with Alzheimer's disease, only cases in which Alzheimer type pathology has been evaluated and only those that meet criteria 3a and 3b are acceptable. <ol type="a"> <li>Neuritic plaques must be no more than sparse in the neocortex. Neuritic plaques are defined according to the CERAD criteria (see figure), which requires assessment with either an appropriate silver stain or thioflavin S fluorescent microscopy. This criterion does not exclude cases with diffuse, non-neuritic plaques, which may be frequent, as long as the case also meets criterion 3b.</li> <li>Neurofibrillary tangle stage must be no more than Stage IV.</li> </ol> </li> </ol> Collaborators - Dennis W. Dickson, MD - Mayo Clinic, Jacksonville, Morris K. Udall Center of Excellence in Parkinson's Disease Research, Jacksonville, FL, USACollaborators - Thomas Beach, MD, PhD - Banner Sun Health Research Institute, Sun City, AZ, USACollaborators - Thomas J. Montine, MD, PhD - University of Washington, Morris K. Udall Center of Excellence in Parkinson's Disease Research, Washington, DC, USACollaborators - Vivianna Van Deerlin, MD, PhD - University of Pennsylvania, Morris K. Udall Center of Excellence in Parkinson's Disease Research, Philadelphia, PA, USACollaborators - James Leverenz, MD - University of Washington, Morris K. Udall Center of Excellence in Parkinson's Disease Research, Washington, DC, USACollaborators - Ted M. Dawson, MD, PhD - Johns Hopkins School of Medicine, Morris K. Udall Center of Excellence in Parkinson's Disease Research, Baltimore, MD, USACollaborators - Samuel M. Goldman, MD, MPH - The Parkinson's Institute and Clinical Center, Sunnyvale, CA, USACollaborators - Tatiana M. Foroud, PhD - Indiana University School of Medicine, Indianapolis, IN, USAFunding Source - X01 HG006076-01 - National Institutes of Health, Bethesda, MD, USACollaborators - Karen Marder, MD, MPH - Columbia University, Morris K. Udall Center of Excellence in Parkinson's Disease Research, New York, NY, USACollaborators - Jeffery Vance, MD, PhD - University of Miami, Morris K. Udall Center of Excellence in Parkinson's Disease Research, Miami, FL, USACollaborators - Deborah Mash, PhD - University of Miami, Morris K. Udall Center of Excellence in Parkinson's Disease Research, Miami, FL, USAFunding Source - P50 NS071674-01S1 - National Institutes of Health, Bethesda, MD, USAFunding Source - P50 NS072187-01S2 - National Institutes of Health, Bethesda, MD, USAFunding Source for Genotyping - HHSN268201100011I - National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USACollaborators - Harry Vinters, MD - University of California, Los Angeles, CA, USACollaborators - John Q. Trojanowski, MD, PhD - University of Pennsylvania, Morris K. Udall Center of Excellence in Parkinson's Disease Research, Philadelphia, PA, USAPrincipal Investigator - Jeffery Vance, MD, PhD - University of Miami, Miami, FL, USACollaborators - Matthew P. Frosch, MD, PhD - Massachusetts General Hospital, Boston, MA, USAdbGaPParkinson's syndrome, Genome-Wide Association, Psychological Power, Parkinsons, Parkinson's disease, other disease, Primary Parkinsonism, Professional Power, Parkinson's disease NOS, Lewy Body, Genome Wide Association Analysis, Whole Genome Association Study, PARKINSON DIS, disorders, familial, Paralysis agitans, Primary, medical condition, Psychological Powers, PARKINSON DIS IDIOPATHIC, Genome-Wide, IDIOPATHIC PARKINSON DIS, Associations., Idiopathic Parkinson Disease, LEWY BODY PARKINSON DIS, Personal, Idiopathic Parkinson's Disease, GWA Studies, Paralysis Agitans, diseases, Genome Wide Association Study, Parkinson's Disease, Lewy Body Parkinson Disease, Diseases, Studies, disease or disorder, condition, diseases and disorders, Professional, Whole Genome Association Analysis, Psychological, average, study, GWA Study, human disease, Parkinsons disease, Parkinson disease, Parkinson's disease (disorder), PARK, GWA, IDIOPATHIC PARKINSONS DIS, Idiopathic PD, Genome Wide Association Studies, Genome Wide Association Scan, Genome-Wide Association Studies, Lewy Body Parkinson's Disease, Parkinsonian disorder, non-neoplastic, Social, genetic, Study, Parkinson's, disease, Personal Power, Idiopathic, Parkinson's disease NOS (disorder), paralysis agitans, PARKINSONS DIS IDIOPATHIC, Power (Psychology), Parkinson Disease, Parkinsonism, Association Studies, PARKINSONS DIS, disorder, Homo sapiens disease, Parkinson syndrome, PD, inherited genetic, Association Study, Social Power, Powers, constitutitional genetic, hereditary, PARKINSONS DIS LEWY BODY, PowerfalseAutopsy-Confirmed Parkinson Disease GWAS Consortium (APDGC)The APDGC was formed to conduct a genome-wide association study in individuals with neuropathologically confirmed Parkinson Disease (PD) and neuropathologically normal controls. The rationale for the study is that including only cases and controls with neuropathologically confirmed disease status will reduce diagnostic misclassification and increase power to detect novel genetic associations.2012-06-222011-08-10phs000394Parkinson Disease