dbGaPapplication/xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000407/phs000407.v1.p1/manifest/manifest_phs000407.NIMH_IMAGE_II.v1.p1.c1.ADHD.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000407/phs000407.v1.p1/manifest/Study_Report.phs000407.NIMH_IMAGE_II.v1.p1.MULTI.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000407/phs000407.v1.p1/release_notes/Release_Notes.phs000407.IMAGEII.v1.p1.MULTI.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000407/phs000407.v1.p1/GapExchange_phs000407.v1.p1.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000407/phs000407.v1.p1/pheno_variable_summaries/phs000407.v1.pht002647.v1.dbGaP_Sample.data_dict.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000407/phs000407.v1.p1/pheno_variable_summaries/phs000407.v1.pht002646.v1.p1.dbGaP_Subject.var_report.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000407/phs000407.v1.p1/pheno_variable_summaries/phs000407.v1.pht002647.v1.p1.dbGaP_Sample.var_report.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000407/phs000407.v1.p1/pheno_variable_summaries/phs000407.v1.pht002646.v1.dbGaP_Subject.data_dict.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000407/phs000407.v1.p1/pheno_variable_summaries/varreports_v3.xslftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000407/phs000407.v1.p1/dbGaPEx2.1.5.xsdftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000407/phs000407.v1.p1/pheno_variable_summaries/datadict_v2.xslprimaryOK200GenomicCase SetIMAGE, wide, whole genome, wide/broad, broad, Genomes, Associations.<p>Inclusion Criteria: Cases were primarily of Caucasian European ancestry recruited in the UK, USA, Netherlands, Belgium, Ireland, and Germany with a diagnosis of ADHD either using DSM-IV or ICD-10 criteria. Subjects recruited were between the ages of 6-17 years.</p> <p>All cases were recruited with informed consent of parents and/or guardians and with the approval of the site&#39;s Institutional Review Board (IRB) or Ethical Committee. Exclusion Criteria: Cases were excluded if they had an IQ&lt;70, autism, epilepsy, a neurological disorder of the CNS, or a genetic disorder that mimics ADHD. </p>https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000407<p>We used case-control analyses of 896 cases with DSM-IV ADHD genotyped using the Affymetrix 5.0 array and 2,455 repository controls screened for psychotic and bipolar symptoms genotyped using Affymetrix 6.0 arrays. A consensus SNP set was imputed using BEAGLE 3.0, resulting in an analysis dataset of 1,033,244 SNPs. The data were analyzed using a generalized linear model. No genome-wide significant associations were found. The most significant results implicated the following genes: PRKG1, FLNC, TCERG1L, PPM1H, NXPH1, PPM1H, CDH13, HK1 and HKDC1 and suggest that the effects of ADHD risk variants must, individually, be very small and/or include multiple rare alleles.</p>Funding Source - NHMRC - S. Medland - National Health and Medical Research Council, AustraliaFunding Source - Sidney Sax Public Health Fellowship - S. Medland - National Health and Medical Research Council, AustraliaCo-Investigator - Jasmin Romanos - University of Würzburg, Würzburg, GermanyCo-Investigator - Barbara Franke - Radboud University, Nijmegen, The NetherlandsCo-Investigator - Herbert Roeyers - Ghent University, Ghent, BelgiumCo-Investigator - Richard Anney - Trinity College, Dublin, IrelandCo-Investigator - Anita Thapar - Cardiff University, Cardiff, UKCo-Investigator - Joseph Sergeant - Vrije University, Amsterdam, The NetherlandsCo-Investigator - Stephen Ripke - Massachusetts General Hospital; The Broad Institute of Harvard and MIT, Boston, MA, USACo-Investigator - Mark Daly - Massachusetts General Hospital; The Broad Institute of Harvard and MIT, Boston, MA, USAFunding Source - International Multi-Center ADHD Genetics Project - S.V. Faraone - National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USACo-Investigator - Michael Gill - Trinity College, Dublin, IrelandCo-Investigator - Jobst Meyer - University of Trier, Trier, GermanyCo-Investigator - Susanne Walitza - University of Würzburg, Würzburg, Germany; University of Zürich, Zürich, SwitzerlandFunding Source - RE 1632/5-1 - A. Reif - Deutsche Forschungsmeinschaft, GermanyCo-Investigator - Christine Freitag - University of Homburg, Homburg, GermanyCo-Investigator - Aribert Rothenberger - University of Göttingen, Göttingen, GermanyCo-Investigator - Helmut Schäfer - University of Marburg, Marburg, GermanyPrincipal Investigator - Stephen V. Faraone - SUNY Upstate Medical University, Syracuse, NY, USACo-Investigator - Tobias Renner - University of Würzburg, Würzburg, GermanyCo-Investigator - Andreas Reif - University of Würzburg, Würzburg, GermanyFunding Source - 2/5 The Psychiatric GWAS Consortium: Integrated and Coordinated GWAS Meta-Analysis - S.V. Faraone - National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USACo-Investigator - Ziarih Hawi - Trinity College, Dublin, IrelandFunding Source - SCHA542/10-3- H. Schäfer - Deutsche Forschungsmeinschaft, GermanyCo-Investigator - Jan Buitelaar - Radboud University, Nijmegen, The NetherlandsCo-Investigator - Benjamin Neale - The Broad Institute of Harvard and MIT, Boston, MA, USACo-Investigator - Haukur Palmason - University of Trier, Trier, GermanyFunding Source - KFO 123, SFB TRR58 - K. P. Lesch and A. Reif - Deutsche Forschungsmeinschaft, GermanyFunding Source - Analysis of an ADHD Whole Genome Association Scan - S.V. Faraone - National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USAFunding Source - Power Award - B. Franke - Affymetrix, USAFunding Source - ME 1923/5-1, ME 1923/5-3 - C. Freitag and J. Meyer - Deutsche Forschungsmeinschaft, GermanyCo-Investigator - Eric Mick - Harvard Medical School, Massachusetts General Hospital, Boston, MA, USACo-Investigator - Philip Asherson - Kings College, London, UKFunding Source - SFB 581, GRK 1156 - K. P. Lesch - Deutsche Forschungsmeinschaft, GermanyCo-Investigator - Marcel Romanos - University of Würzburg, Würzburg, GermanyCo-Investigator - Andreas Warnke - University of Würzburg, Würzburg, GermanyCo-Investigator - Frank Middleton - SUNY Upstate Medical University, Syracuse, NY, USAFunding Source - Collaborative ADHD Genetics Conference - S.V. Faraone - National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USACo-Investigator - Klaus Peter Lesch - University of Würzburg, Würzburg; University of Homburg, Homburg, GermanyCo-Investigator - Thuy Trang Nguyen - University of Marburg, Marburg, GermanyFunding Source - BMBF 01GV0605 - K. P. Lesch - Bundesministerium für Bildung und Forschung, GermanyFunding Source - Wellcome Trust - L. Kent and A. Thapar - Wellcome Trust, UKCo-Investigator - Sarah Medland - The Broad Institute of Harvard and MIT, Boston, MA, USA; Queensland Institute of Medical Research, Herston, AustraliadbGaPMental, activated cell autonomous cell death, MGC130048, other disease, paralysis periodica Paramyotonica, Disorders, F12K11.4, SGCG_HUMAN, l(3)05592, young adult, DEIH-BOX RNA/DNA HELICASE, A4, atado, Hyperkinetic, Selective, broad, TYPE, prevention, DAGA4, Northern Europe, diseases, DmelCG1007, Associations, nuclear DEIH-boxhelicase, Minimal, CHILD, 35DAG, Deficit-Hyperactivity Disorders, disease or disorder, Brain Dysfunction, diseases and disorders, F12K11_4, MAM, gamma-SG, Southern Europe, interstitial lung disease of childhood, SCG3, prevention and control, ADHD, gamma sarcoglycan, l(3)04322, human disease, reference sample, Genomes, Deficit Disorder, CG12352, l(3)j4E11, Hyperkinetic disorder, paediatric interstitial lung disease, chILD, Social, non-neoplastic, preventive measures, juvenile stage, Deficit Disorders, activated T cell apoptosis, Ach, Social Attention, Concentration, sample, Disorder, DmelCG12352, childhood interstitial lung disease, Attention Deficit Disorder, GOV, l(3)61Da, gamma-sarcoglycan, disorder, Homo sapiens disease, Attention Deficit, DmAAF34715, PubMed., Controlled, span, ADD, Controlling, RAD3D, preventive therapy, Attention Deficit-Hyperactivity Disorder, wide/broad, cHILD, pediatric interstitial lung disease, 35 kDa dystrophin-associated glycoprotein, D2-2, PubMed, Attention Deficit Disorders with Hyperactivity, Attention Deficit-Hyperactivity Disorders, Dm0688, gov, SG-gamma, disorders, bHLHb28, Attention Focus, medical condition, Emc, Hyperactive behavior, paramyotonia congenita of VON Eulenburg, SGCG, CG1007, LGMD2C, Attention, Selective Attention, myotonia congenita intermittens, Western Europe, Hyperkinetic Syndrome, condition, sarcoglycan, Eulenburg disease, Attention Deficit Disorders, Dysfunction, Von Eulenburg paramyotonia congenita, Focus of Attention, child, 0977/09, Hyperactive behaviour, Attention Deficit-Hyperactivity, Attention Deficit Hyperactivity Disorders, Minimal Brain, Minimal Brain Dysfunction, DMDA1, ILD specific to childhood, prophylaxis, 0203/10, ms(3)61CD, hyperkinetic disorder, chILD syndrome, Mental Concentration, More active than typical, America, whole genome, gamma (35kDa dystrophin-associated glycoprotein), ACAD, Children, sample population, disease, wide, DMDA, 0587/01, PMC, paramyotonia congenita without cold paralysis, Syndromes, control, 35kD dystrophin-associated glycoprotein, children's interstitial lung disease, SCARMD2, Manuscripts, Attention Deficit Hyperactivity Disorder, 0094/26, ADDH, RAB16, Deficit-Hyperactivity DisorderfalseIMAGE II Genome-Wide Association<p>This sample represents a collection of cases across a range of sites. All of these samples were ascertained for ADHD with most meeting criteria for combined type ADHD. The collection sites span Europe and America. Further details on the source and inclusion and exclusion information can be found in Neale et al. "Case-Control Genome-Wide Association of Attention-Deficit / Hyperactivity Disorder" J Am Acad Child Adolesc Psychiatry. 2010 September; 49(9): 906-920 <a href="http://www.ncbi.nlm.nih.gov/pubmed/20732627">PMID20732627</a>. For online access to this manuscript see: <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928577/?tool=pubmed">PMC2928577</a>.</p>2012-04-262011-09-01phs000407Attention Deficit and Disruptive Behavior Disorders2073262720732625