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ftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000678/phs000678.v1.p1/release_notes/Release_Notes.phs000678.YoungOnsetBreastCancer.v1.p1.MULTI.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000678/phs000678.v1.p1/manifest/Study_Report.phs000678.CIDR_YoungOnset_BreastCancer.v1.p1.MULTI.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000678/phs000678.v1.p1/manifest/manifest_phs000678.CIDR_YoungOnset_BreastCancer.v1.p1.c1.GRU.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000678/phs000678.v1.p1/pheno_variable_summaries/phs000678.v1.pht003565.v1.Young_Onset_Breast_Cancer_Subject_Phenotypes.data_dict.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000678/phs000678.v1.p1/GapExchange_phs000678.v1.p1.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000678/phs000678.v1.p1/pheno_variable_summaries/phs000678.v1.pht003563.v1.p1.Young_Onset_Breast_Cancer_Pedigree.var_report.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000678/phs000678.v1.p1/pheno_variable_summaries/phs000678.v1.pht003566.v1.p1.Young_Onset_Breast_Cancer_Sample_Attributes.var_report.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000678/phs000678.v1.p1/pheno_variable_summaries/phs000678.v1.pht003564.v1.p1.Young_Onset_Breast_Cancer_Sample.var_report.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000678/phs000678.v1.p1/pheno_variable_summaries/phs000678.v1.pht003565.v1.p1.Young_Onset_Breast_Cancer_Subject_Phenotypes.var_report.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000678/phs000678.v1.p1/pheno_variable_summaries/phs000678.v1.pht003566.v1.Young_Onset_Breast_Cancer_Sample_Attributes.data_dict.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000678/phs000678.v1.p1/pheno_variable_summaries/phs000678.v1.pht003563.v1.Young_Onset_Breast_Cancer_Pedigree.data_dict.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000678/phs000678.v1.p1/pheno_variable_summaries/phs000678.v1.pht003564.v1.Young_Onset_Breast_Cancer_Sample.data_dict.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000678/phs000678.v1.p1/pheno_variable_summaries/phs000678.v1.pht003562.v1.p1.Young_Onset_Breast_Cancer_Subject.var_report.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000678/phs000678.v1.p1/pheno_variable_summaries/phs000678.v1.pht003562.v1.Young_Onset_Breast_Cancer_Subject.data_dict.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000678/phs000678.v1.p1/pheno_variable_summaries/datadict_v2.xslftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000678/phs000678.v1.p1/dbGaPEx2.1.5.xsdftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000678/phs000678.v1.p1/pheno_variable_summaries/varreports_v3.xslprimaryOK200GenomicFamilyNetworks, Breast Carcinoma, Human Mammary Neoplasm, primary breast cancer, Carcinoma, malignant tumor of the breast, Materials, Breast Carcinomas, Family Member, Kinship, "breast neoplasm" EXACT [MTH:120], Family Research, Neoplasms, mammary neoplasm, Gene, Mammary Cancers, Human Mammary Neoplasms, Network, Tumor, "breast tumor" EXACT [NCI2004_11_17:C2910], Cistrons, Impact, Human, Family Members, Breast Malignant Neoplasm, Environmental, Breast Malignant Tumor, "neoplasm of breast (disorder)" EXACT [SNOMEDCT_2005_07_31:126926005], Mammary Carcinomas, Breast Tumor, Neoplasm, Life Cycle, Genetic Materials, Impacts, Human Mammary Carcinoma, "mammary tumor" EXACT [CSP2005:2016-0671], NOS, breast tumor, cancer of the breast, Environmental Impacts, Filiation, Malignant Neoplasm of Breast, Genetic Material, Family Life Cycle, Carcinomas, BC, study, Mammary Neoplasms, malignant neoplasm of breast, Human Mammary, Breast Neoplasm, Kinship Network, Genetic, Research, Mammary Neoplasm, Mammary Carcinoma, Human Mammary Carcinomas, Age of onset, Cancers, Breast Malignant Neoplasms., Age symptoms begin, "mammary neoplasm" RELATED [], Cancer of the Breast, Life Cycles, Environmental Impact, breast cancer, Material, cancer of breast, Families, Malignant Tumor of Breast, Mammary, Mammary Cancer, Breast Tumors, Breast Cancer, Environments, Breast Malignant Tumors, Cistron, Cancer of Breast, Kinship Networks, Family Life Cycles, Breast, mammary cancer, Family, Relatives, cancer, mammary tumor, breast, Tumors, CancerControls were women whose sister had been diagnosed with breast cancer. They had to be between 35 and 75 years old, be living in the US or Puerto Rico, and be fluent in either English or Spanish. They agreed to be followed over time, to participate in two lengthy interviews by phone and submit to a blood draw, urine and house dust collection, and measurement of blood pressure and weight. They provided informed consent. Their information included their sister's age at diagnosis and how recently it had occurred. The sister did not have to be living. Cases were women whose full sister was fully enrolled in the Sister Study. They had to be able to answer questions in English and they had to have been diagnosed before age 50 and within 4 years of enrollment. They agreed to be followed over time, to participate in three interviews by phone and provide saliva for DNA extraction via a mail-back kit (Oragene) and they provided informed consent. They were asked to send a letter from us to their parents, inviting them to provide saliva samples. Parents provided informed consent for genotyping. The consent forms all made clear that genotype results would not be returned to participants. When both parents were available, the control sister was not genotyped, as non-transmitted parental alleles can fill that role.https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000678Enrollment was carried out between September, 2008 and December, 2010, and 1422 case sisters were enrolled. When new young-onset (under age 50) cases were reported to study staff during follow-up in the Sister Study, we also asked them to invite their parents to provide a saliva sample. So the study has been augmented by including family members as available for young-onset Sister Study participants. A few of those also had an unaffected sister participating in Sister, but most did not. The study will also be following the case cohort made up of Two Sister cases together with the incident cases from the Sister Study in order to identify genetic and environmental factors that promote healthy and recurrence-free survival.Principal Investigator - Clarice Weinberg, PhD - National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USAFunding Source - Z01-ES044005 - the Intramural Research Program of the National Institutes of Health, Bethesda, MD, USAFunding Source - FAS0703856 - Susan G. Komen for the CureFunding Source - Z01-ES102245 - the Intramural Research Program of the National Institutes of Health, Bethesda, MD, USAhttp://sisterstudy.niehs.nih.gov/English/2sis.htmdbGaPNetworks, malignant tumor of the breast, Kinship, Mail Order, Design, mammary neoplasm, I-kappa-B-zeta, Human Mammary Neoplasms, Xkl-1, Survey Methods, Tumor, Questionnaire Designs, Status, Techniques, KL receptor activity, Gsfsco1, "neoplasm of breast (disorder)" EXACT [SNOMEDCT_2005_07_31:126926005], Survey Methodology, SCO5, Life Cycle, cancer of the breast, Nonrespondents, SCO1, INAP, Gsfsow3, Randomized Response, Gsfsco5, Postal, SOW3, Family Life Cycle, BC, Mammary Neoplasms, malignant neoplasm of breast, AA408868, thymus nucleic acid, Kinship Network, pre-mortem, Human Mammary Carcinomas, Designs, Age of onset, Questionnaires, W, genetic, Mail-Order, Respondents, cancer of breast, sample, Services, Bs, Double-Stranded DNA, deoxyribonucleic acids, DNAn, Family Life Cycles, mammary cancer, Sl, Breast Malignant Neoplasms, Tumors, Carcinoma, Questionnaire, "breast neoplasm" EXACT [MTH:120], Step Parents, familial, Salivas, Tr-kit, Brother, Double-Stranded, Questionnaire Design, Stepparent, Girl, (Deoxyribonucleotide)n+m, PBT, Parenthood, consent, RENBP, Distributions, Step-Parents, kl1-A, NOS, KIT, desoxyribose nucleic acid, Filiation, Malignant Neoplasm of Breast, Carcinomas, tyrosine-protein kinase Kit, pbt, Parent, IkappaBzeta, Parental Age, Nonrespondent, Molecule possessing ankyrin repeats induced by lipopolysaccharide, Mail-Orders, Parental Ages, kit, IKBZ, "mammary neoplasm" RELATED [], Survey Method, Age, AGE, Life Cycles, living, breast cancer, Breast Tumors, ds DNA, Breast Malignant Tumors, Surveys, Sisters, inherited genetic, DNA, cancer, Community, krk1, primary breast cancer, DNS, Family Member, (Deoxyribonucleotide)n, Neoplasms, SCF receptor activity, Mammary Cancers, Mails, Network, IL-1 inducible nuclear ankyrin-repeat protein, Deoxyribonucleic acids, Human, Breast Malignant Tumor, Deoxyribonucleic Acid, scfr, Breast Tumor, Baseline, Girls, Community Survey, Baseline Surveys, saliva molecularis, "mammary tumor" EXACT [CSP2005:2016-0671], Survey, breast tumor, Randomized, Parenthood Status, Randomized Response Techniques, Distribution, SCFR, Stepparents, study, Brothers, Methodology, Postal Services, Fdc, alive, Human Mammary, Research, Mammary Neoplasm, Mammary Carcinoma, saliva atomaris, study., Double Stranded, Deoxyribonucleic acid, Respondent, Questionnaires and Surveys, Cancer of the Breast, Malignant Tumor of Breast, Ages, Mammary, Mammary Cancer, Randomized Response Technique, (Deoxyribonucleotide)m, Kinship Networks, Breast, constitutitional genetic, Family, mammary tumor, Cancer, Repeated Rounds of Survey, Breast Carcinoma, Human Mammary Neoplasm, proto-oncogene c-Kit, IkB-zeta, Breast Carcinomas, whole blood, Family Research, Women's Group, RnBP, DNAn+1, Women Groups, Parental, GlcNAc 2-epimerase, MAIL, "breast tumor" EXACT [NCI2004_11_17:C2910], RGD1310834, Woman, Breast Malignant Neoplasm, Family Members, N-acetyl-D-glucosamine 2-epimerase, Mammary Carcinomas, KIT ligand receptor activity, Mail Distribution, Neoplasm, Human Mammary Carcinoma, Step-Parent, ds-DNA, Methods, XKrk1, Community Surveys, Response Techniques, c-KIT, Breast Neoplasm, Sibling, Response Technique, Women's Groups, Cancers, Age symptoms begin, CD117, Sister, sample population, Baseline Survey, c-kit, Service, C-Kit, Families, Ssm, Breast Cancer, Desoxyribonukleinsaeure, xkl-1, renin-binding protein, Cancer of Breast, Mail, sailva normalis, hereditary, Mail Distributions, Relatives, breastfalseA Family-Based Study of Genes and Environment in Young-Onset Breast CancerTo study environmental and genetic causes of young onset breast cancer, we recruited women who had been young when recently diagnosed (under age 50 and within 4 years of enrollment), and had been identified as potentially eligible by a sister who was already participating in the ongoing Sister Study. The unaffected sister had already provided consent, questionnaire-based information and DNA (blood-based) when she enrolled in the Sister Study. Her case sister then provided comparable questionnaire-based information and DNA via a mail-back saliva collection kit. To enable family-based analyses, parents were also asked to (only) provide consent and a saliva sample. Because the cases were young-onset, most parents were alive, but unavailability of the parents was not a basis for exclusion. The study was funded in part by Susan G. Komen for the Cure.2013-11-052013-11-05phs000678Breast Neoplasms22021562232482142277382523021929