dbGaPapplication/xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000728/phs000728.v1.p1/manifest/manifest_phs000728.LungCancerSusceptibility.v1.p1.c2.DS-LC.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000728/phs000728.v1.p1/manifest/Study_Report.phs000728.LungCancerSusceptibility.v1.p1.MULTI.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000728/phs000728.v1.p1/manifest/manifest_phs000728.LungCancerSusceptibility.v1.p1.c1.GRU.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000728/phs000728.v1.p1/release_notes/Release_Notes.phs000728.LungCancerSusceptibility.v1.p1.MULTI.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000728/phs000728.v1.p1/pheno_variable_summaries/phs000728.v1.pht003768.v1.Lung_Cancer_Smokers_Sample_Attributes.data_dict.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000728/phs000728.v1.p1/GapExchange_phs000728.v1.p1.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000728/phs000728.v1.p1/pheno_variable_summaries/phs000728.v1.pht003768.v1.p1.Lung_Cancer_Smokers_Sample_Attributes.var_report.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000728/phs000728.v1.p1/pheno_variable_summaries/phs000728.v1.pht003766.v1.Lung_Cancer_Smokers_Subject.data_dict.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000728/phs000728.v1.p1/pheno_variable_summaries/phs000728.v1.pht003766.v1.p1.Lung_Cancer_Smokers_Subject.var_report.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000728/phs000728.v1.p1/pheno_variable_summaries/phs000728.v1.pht003767.v1.p1.Lung_Cancer_Smokers_Sample.var_report.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000728/phs000728.v1.p1/pheno_variable_summaries/phs000728.v1.pht003767.v1.Lung_Cancer_Smokers_Sample.data_dict.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000728/phs000728.v1.p1/pheno_variable_summaries/datadict_v2.xslftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000728/phs000728.v1.p1/pheno_variable_summaries/varreports_v3.xslftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000728/phs000728.v1.p1/dbGaPEx2.1.5.xsdprimaryOK200GenomicFamilyCancer of the lung, Malignant tumor of lung, Pulmonary Neoplasms, Lung cancer, Lung, Vapers, malignant lung tumor, Neoplasms, lung cancer, Cancer of Lung, Tobacco Smoker, Non-Tobacco Products Smoker, malignant tumor of lung, Non Tobacco Products, malignant neoplasm of the lung, somatic, Vaper, autosomal dominant, Smokers, cancer of lung, malignant lung tumour, Nonsmall cell lung cancer, Neoplasm, Tobacco, Malignant lung tumor, malignant tumour of lung, Pulmonary Cancer, Pulmonary cancer, Pulmonary, Lung Cancer, Lung malignant tumors, susceptibility, malignant tumor of the lung, malignant tumour of the lung, malignant lung neoplasm, Pulmonary Neoplasm, adenocarcinoma of lung, alveolar cell carcinoma, susceptibility to, LNCR, Smoker, Lung Cancers, Cancers, Tobacco Smokers, response to tyrosine kinase inhibitor in, Non-Tobacco Products Smokers, nonsmall cell lung cancer, resistance to, Malignant neoplasm of lung, Lung Neoplasm, malignant neoplasm of lung, Tobacco., protection against, Pulmonary Cancers, Cancer of the Lung, lung neoplasm, Non-Tobacco Products, somatic mutation, Cancerhttps://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000728Co-Investigator and Sample Provider - Colette Glynn Gaba, MPH - University of Toledo, Toledo, OH, USACo-Principal Investigator - Li Ding, PhD - Washington University School of Medicine, St. Louis, MO, USACo-Investigator and Sample Provider - Diptasri Mandal, PhD - Louisiana State University, New Orleans, LA, USACo-Investigator and Sample Provider - Marshall W. Anderson, PhD - Medical College of Wisconsin, Milwaukee, WI, USAPrincipal Investigator - Susan K. Dutcher, PhD - Washington University School of Medicine, St. Louis, MO, USACo-Investigator and Sample Provider - Ann Schwartz PhD, MPH - Barbara Anne Karmanos Cancer Institute, Wayne State University, Detroit, MI, USACo-Investigator and Sample Provider - Joan E. Bailey-Wilson, PhD - National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USACo-Investigator and Sample Provider - Ping Yang, MD, PhD - Mayo Clinic, Rochester, NY, USACo-Principal Investigator - Ramaswamy Govindan, MD - Washington University School of Medicine, St. Louis, MO, USACo-Investigator and Sample Provider - Ming You, MD, PhD - Medical College of Wisconsin, Milwaukee, WI, USACo-Investigator and Sample Provider - Mariza de Andrade, PhD - Mayo Clinic, Rochester, MN, USCo-Investigator and Sample Provider - Susan M. Pinney, PhD - University of Cincinnati College of Medicine, Cincinnati, OH, USAFunding Source - U54 HG003079 - National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USAdbGaPCancer of the lung, Networks, Malignant tumor of lung, Lung, Family Member, Kinship, DNS, (Deoxyribonucleotide)n, Aspect, Vapers, malignant lung tumor, Neoplasms, lung cancer, Non-Tobacco Products Smoker, malignant tumor of lung, malignant neoplasm of the lung, Progress Reports, Network, autosomal dominant, Deoxyribonucleic acids, Relative, Smokers, Investigative, Deoxyribonucleic Acid, resilient, Summary Report, tough, Studies, Tobacco, Life Cycle, Pulmonary Cancer, Summary Reports, Pulmonary cancer, Pulmonary, Epidemiologic Study, Family Life Cycle, strong, Lung Cancer, thymus nucleic acid, malignant tumour of the lung, Kinship Network, Progress Report, Research, alveolar cell carcinoma, LNCR, Double Stranded, Lung Cancers, Deoxyribonucleic acid, Histories, Tobacco Smokers, Study, Progress, Tobacco Consumption, Non-Tobacco Products Smokers, resistance to, Malignant neoplasm of lung, Field Reports, Lung Neoplasm, Clients, malignant neoplasm of lung, Double-Stranded DNA, (Deoxyribonucleotide)m, Kinship Networks, deoxyribonucleic acids, Family Life Cycles, DNAn, Investigative Reports, Non-Tobacco Products, Family, somatic mutation, Epidemiological, Cancer, Pulmonary Neoplasms, Lung cancer, Tobacco Uses, Family Research, Epidemiologic, DNAn+1, Cancer of Lung, Tobacco Smoker, Nicotiana tabacum var. Samsun, Non Tobacco Products, Double-Stranded, Historical Aspects, Epidemiological Studies, somatic, historical aspects, tobacco, Vaper, Client, Historical Aspect, Consumption, Family Members, (Deoxyribonucleotide)n+m, Investigative Report, cancer of lung, Nicotania tabacum, Research Reports, Relative Risks, malignant lung tumour, Nonsmall cell lung cancer, Neoplasm, Malignant lung tumor, malignant tumour of lung, Epidemiological Study, ds-DNA, American tobacco, Filiation, desoxyribose nucleic acid, Relative Risk, Lung malignant tumors, malignant tumor of the lung, malignant lung neoplasm, Risk, Pulmonary Neoplasm, adenocarcinoma of lung, susceptibility to, Risks, Field, Smoker, Cancers, somatic., response to tyrosine kinase inhibitor in, Life Cycles, Report, nonsmall cell lung cancer, Patient, Reports, Tobacco Chewing, Families, historical notes, common tobacco, ds DNA, Desoxyribonukleinsaeure, protection against, Pulmonary Cancers, Cancer of the Lung, lung neoplasm, DNA, Aspects, Summary, Relatives, Field Report, HistoricalfalseLung Cancer Susceptibility in Smokers<p>Over 85% of all patients diagnosed with lung cancer report a history of tobacco use, though only 10% of tobacco smokers eventually develop lung cancer. Epidemiologic studies have shown that family members of patients with lung cancer have a higher risk of developing lung cancer than controls. In an effort to identify variants associated with tobacco induced lung cancer, we have sequenced germline DNA from affected and unaffected members of families with strong histories of tobacco related lung cancer.</p>2018-01-262014-03-18phs000728Lung Neoplasms