dbGaPapplication/xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000730/phs000730.v1.p1/manifest/manifest_phs000730.BrainMetastasis.v1.p1.c3.GRU-NPU.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000730/phs000730.v1.p1/manifest/Study_Report.phs000730.BrainMetastasis.v1.p1.MULTI.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000730/phs000730.v1.p1/manifest/manifest_phs000730.BrainMetastasis.v1.p1.c2.DS-CRM.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000730/phs000730.v1.p1/manifest/manifest_phs000730.BrainMetastasis.v1.p1.c1.GRU.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000730/phs000730.v1.p1/release_notes/Release_Notes.phs000730.BrainMetastasis.v1.p1.MULTI.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000730/phs000730.v1.p1/pheno_variable_summaries/phs000730.v1.pht005059.v1.Brain_Metastasis_Sample.data_dict.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000730/phs000730.v1.p1/pheno_variable_summaries/phs000730.v1.pht005061.v1.Brain_Metastasis_Sample_Attributes.data_dict.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000730/phs000730.v1.p1/pheno_variable_summaries/phs000730.v1.pht005060.v1.Brain_Metastasis_Subject_Phenotypes.data_dict.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000730/phs000730.v1.p1/pheno_variable_summaries/phs000730.v1.pht005061.v1.p1.Brain_Metastasis_Sample_Attributes.var_report.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000730/phs000730.v1.p1/pheno_variable_summaries/phs000730.v1.pht005060.v1.p1.Brain_Metastasis_Subject_Phenotypes.var_report.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000730/phs000730.v1.p1/pheno_variable_summaries/phs000730.v1.pht005058.v1.p1.Brain_Metastasis_Subject.var_report.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000730/phs000730.v1.p1/GapExchange_phs000730.v1.p1.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000730/phs000730.v1.p1/pheno_variable_summaries/phs000730.v1.pht005059.v1.p1.Brain_Metastasis_Sample.var_report.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000730/phs000730.v1.p1/pheno_variable_summaries/phs000730.v1.pht005058.v1.Brain_Metastasis_Subject.data_dict.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000730/phs000730.v1.p1/pheno_variable_summaries/varreports_v3.xslftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000730/phs000730.v1.p1/dbGaPEx2.1.5.xsdftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000730/phs000730.v1.p1/pheno_variable_summaries/datadict_v2.xslprimaryOK200GenomicCase Setthe brain, Genomics, suprasegmental structures, Structural, Comparative, Comparative Genomics, Functional, Structural Genomics, synganglion, Functional Genomics, suprasegmental levels of nervous system, encephalon, Encephalon.https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000730Funding Source - U54HG003067 - National Institutes of Health, Bethesda, MD, USAPrincipal Investigator - Priscilla Brastianos - Broad Institute, Cambridge, MA, USAdbGaPthe brain, big, Brain, other disease, Brain Tumors, Antemortem Diagnosis, determination, Metastasis, Complete Exome, Neoplasms, Brain Neoplasms, number, Mbp1, Neoplasm Metastases, neoplasm metastasis, Tumor, Diagnosis, presence, froggy, cancer metastasis, Gyltl1a, large, Readability, Recurrent Brain Tumors, diseases, INTRACRANIAL NEOPL, Recurrent, Mass, symptoms, Screening, disease or disorder, diseases and disorders, synganglion, Whole Transcriptome, Transcriptome Sequencing, Antemortem, myd, adult, average, tumor cell migration, WES, human disease, Complete, Exome Sequencings, brain neoplasms, MDDGB6, Complete Exome Sequencing, Whole Transcriptome Sequencing, Tissue, Mbp-1, metastasis, LARGE, Brain Tumor, Diagnoses and Examinations, suprasegmental levels of nervous system, Sequencing, non-neoplastic, BPFD#36, Whole Exome, PRIMARY BRAIN NEOPL, neoplasm of brain, time of survival, Clients, great, Recurrent Brain Tumor, Whole, disorder, Homo sapiens disease, Nucleotide, tumor metastasis, Diagnose, tumor of brain, NEOPL INTRACRANIAL, Tumors, Antemortem Diagnoses, screening, suprasegmental structures, findings, Intracranial Neoplasm, brain neoplasm, Complete Exome Sequencings, gyltl1b-b, Metastases, Exome, disorders, medical condition, NEOPL BRAIN, encephalon, Client, Examination and Diagnoses, Diagnoses, Metastase, Exome Sequencing, count in organism, survival, Postmortem, Screenings, Mass Screenings, MDDGA6, Examinations and Diagnoses, mKIAA0609, chemical analysis, Diseases, Neoplasm, condition, median, simple tissue, Postmortem Diagnosis, KIAA0609, Adults, nucleotides, Intracranial Neoplasms, Diagnoses and Examination, fg, Postmortem Diagnoses, Complete Transcriptome, brain neoplasm (disease), gyltl1b, Complete Transcriptome Sequencing, death rate, Encephalon, mdc1d, expanded, signs, patient, tumor of the Brain, Understanding, Intracranial, MDC1D, disease, metastatic, Tree., neoplasm of the brain, enr, enlarged, brain tumor, Patient, cardinality, Whole Exome Sequencing, assay, Transcriptome SequencingsfalseGenomics of Brain Metastases<p>Brain metastases are the most frequently occurring intracranial tumors in adults. Median survival after the diagnosis of a brain metastasis is in the order of a few months. Despite its large burden of disease and devastating clinical sequelae, we continue to have a limited understanding of the molecular mechanisms driving brain metastasis. We subjected 86 trios consisting of primary tumor, brain metastasis, and matched normal tissue to whole exome sequencing (WES). To analyze the data, we developed novel computational tools to perform an integrative analysis of somatic single nucleotide variants (SSNVs) and somatic copy-number alterations (SCNAs). This analysis allowed us to estimate the clonal architecture of the primary and metastatic samples of each patient, and to reconstruct a phylogenetic tree relating all of the subclones.</p>2015-11-102014-03-19phs000730Neoplasms