All breast cancer cases were estrogen receptor negative (confirmed through medical records), and all prostate cancer cases either had high histologic grade (Gleason score ≥ 8) or extraprostatic extension (Stage C/D) (confirmed through medical records). Controls were matched to cases on gender and required to be cancer-free and alive at that matched case's age at diagnosis.
"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000812"],"study_history":[null],"Breast and Prostate Cancer Cohort Consortium (BPC3)":["http://epi.grants.cancer.gov/BPC3/"],"attribution":["Principal Investigator - David Hunter, ScD - Harvard School of Public Health, Boston, MA, USA","Principal Investigator - Michael Thun - American Cancer Society, USA","Principal Investigator - Montserrat Garcia-Closas - The Institute for Cancer Research, London, United Kingdom","Principal Investigator - Jonine D. Figueroa - National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","Principal Investigator - Elio Riboli - The Imperial College of Science, Technology and Medicine, London, United Kingdom","Funding Source - U01 CA098233 - National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","Principal Investigator - Brian Henderson - University of Southern California, Los Angeles, CA, USA","Funding Source - U01 CA098710 - National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","Funding Source - Intramural Funds - National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","Funding Source - U01 CA098758 - National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","Principal Investigator - Susan Gapstur - American Cancer Society, USA","Funding Source - U01 CA098216 - National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"],"repository":["dbGaP"],"description_synonyms":["Genome-Wide 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GCPS, MaxCaro, Case-Referrent."],"additional_accession":[]},"is_claimable":false,"name":"The Breast and Prostate Cancer Cohort Consortium (BPC3)","description":"The Breast and Prostate Cancer Cohort Consortium (BPC3) was established in 2003 to pool data and biospecimens from nine large prospective cohorts to conduct research on gene-environment interactions in cancer etiology. The BPC3 initially focused on the association of >70 candidate genes in the Steroid Hormone Metabolism and IGF pathways with risk of breast and prostate cancer. The Consortium's work expanded in 2007 to include genome-wide association studies of estrogen receptor negative (ER-) breast cancer and aggressive prostate cancer. ER- breast cancers have specific epidemiologic characteristics and greater lethality, suggesting ER- breast cancer has a different etiology than ER+ breast cancer. Similarly, aggressive forms of prostate cancer, characterized by extraprostatic extension (Stage C/D) or high histologic grade (Gleason score 8+), differ epidemiologically from the vastly more common indolent forms of prostate cancer and are of the greatest clinical importance. By restricting cases to these specific subtypes, the BPC3 GWAS increased power to detect loci associated with ER- and aggressive prostate cancer (Kraft P and Haiman CA, Nature Genetics 2010 Oct;42:819-20, PMID: 20877320 ).
The BPC3 GWAS includes the following cohorts: the American Cancer Society Cancer Prevention Study-II (CPS-II); the European Prospective Investigation of Cancer (EPIC); the Physician's Health Study (PHS); the Nurses' Health Studies I and II (NHS and NHSII); the Health Professionals Follow-up Study (HPFS); the Multiethnic Cohort (MEC); the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial; and the Alpha-Tocopherol, Beta-Carotene (ATBC) Study.
For the GWAS of ER- cancer, the BPC3 was expanded to include the Polish Breast Cancer Study (PBCS), a population-based case-control study.
","dates":{"last_modification":"2014-10-06","creation":"2014-10-06"},"accession":"phs000812","cross_references":{"MESH":["Prostatic Neoplasms"],"PMID":["21743057","16755295","22976474"]}}