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Whiteman, PhD - Cancer Control, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia"],"repository":["dbGaP"],"description_synonyms":["extent, Genome-Wide Association, host organism, premalignant state, Activity, predisposition, Laboratory, Whole Genome Association Study, NetrinA, D430049E23Rik, Visible Light, Preneoplastic Condition, CG30327, Adiposis, Relative, CG11478, School-Age, Obese, unspecified, premalignant condition, Associations, hnu, pathogenesis, Research Activity, Laboratory Research, foton, IKKg, Epidemiologic Study, KEY, Key, Priorities, GWA Study, DmelCG42257, Elkh, esophagus adenocarcinoma, Genetic Predisposition, 1110030M22Rik, EK6, Genetic Susceptibilities, SAP-2, Sap-2, genetic predispositions, Genome-Wide Association Studies, genetic, neuroendocrine tumour, TNFSF14, Solute carrier family 6 member 2, CT27014, NET1, SLC6A5, Research Priority, netA, gullet, adenocarcinoma of esophagus, gamma, Elk, ELK, Radiation, completeness, UNQ391/PRO726, Neuronally-expressed EPH-related tyrosine kinase, Epidemiologic, Research Priorities, SAP2, Light, 9330129L11, Epidemiological Studies, Genome-Wide, results, neuroendocrine neoplasm, DmIKKgamma, LIGHT, Precancerous Condition, Genome Wide Association Study, Norepinephrine transporter, dIKK, School Age, CG6393, Relative Risks, Kenny, Obesity [Ambiguous], Obese (finding), EPH-like kinase 6, OBESITY, beacon, esophageal adenocarcinoma, Whole Genome Association Analysis, Preneoplastic Conditions, Smoking, Research and Development, Preneoplastic, Visible Radiations, Populations, Dmel_CG6393, tobacco use disorder, Visible Radiation, HVEML, Risk, adenocarcinoma of oesophagus, IKK-gamma, Adiposity, OBESITY NOS, Predisposition, hEK6, adenocarcinoma of the esophagus, Activities, Condition, DmelCG18657, metastatic, oesophageal adenocarcinoma, light quantum, DmelCG16910, adenocarcinoma of the oesophagus, Association Study, School-Age Population, AW488255, genetic susceptibilities, Genome Wide Association Analysis, Cigarette, Goal, obesity disease, Precancerous, genetic predisposition, dIKK-gamma, adenocarcinoma - oesophagus, netrin, Ly113, Obesity, Susceptibility, EAC, GWA Studies, Hek6, DmIKK-gamma, Studies, Cek6, dmIKKgamma, IKK[[gamma]], ENSMUSG00000074119, ERP, APUDoma, Erp, School-Age Populations, study, oesophagus adenocarcinoma, Genetic, Research, Lichtquant, GWA, Having too much body fat, Tyrosine-protein kinase receptor EPH-2, Overweight and obesity, causes, Visible, Population, Genome Wide Association Scan, Study, 2.7.10.1, IKK, Predispositions, Etrp, 65K, CG42257, Dmel_CG30327, causality, photon, NAT1, snp, Development and Research, TR2, School Age Population, adenocarcinoma - esophagus, NET, Net, Epidemiological, cg11478, precancerous state, C130099E04Rik, Conditions, EPH tyrosine kinase 2, neuroendocrine tumor, CD258, net, genetic susceptibility, obesity, IKKgamma, Priority, Research Activities, Epidemiological Study, epistatic, oesophagus, Genetic Predispositions, obesity disorder, Obesity (disorder), Relative Risk, Radiations, susceptibility, Dmikkgamma, HVEM-L, Obesity NOS, Risks, Photoradiation, CG16910, CG18657, predispositions, School Age Populations, Genome Wide Association Studies, Susceptibilities, LTg, Photoradiations, EPHT2, Genetic Susceptibility, Association Studies, precancerous condition, epistatic genetic interaction (sensu inequality)., susceptibilities, netrin A, esophagus"],"additional_accession":[]},"is_claimable":false,"name":"Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study (BEAGESS)","description":"

BEAGESS is a genome-wide association study (GWAS) which takes advantage of the extensive data collected by investigators in the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON, http://beacon.tlvnet.net), representing many of the high-quality population-based and other epidemiologic studies of BE and EA in the world. The overall goal of our research is to evaluate the influence of genetic susceptibility on risk of EA and its main precancerous condition, BE.

The primary aims of the study are to identify tagSNPs most strongly associated with risk of esophageal adenocarcinoma (EA) and Barrett's esophagus (BE). In the secondary aims we will evaluate the extent to which the most significant associations vary according to key environmental and host factors for these conditions, including gender, obesity and cigarette smoking. These results will guide additional exploratory analyses examining ways in which individual SNP results might be aggregated to shed light in the importance of specific pathways relevant to the etiology of BE and EA, and to identify possible epistatic effects.

","dates":{"last_modification":"2015-04-01","creation":"2015-02-11"},"accession":"phs000869","cross_references":{"MESH":["Barrett Esophagus"],"PMID":["24121790","24168968","25447851","25269698","22961001","24943595","24530603","25280564"]}}