{"database":"dbGaP","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Pdf":["ftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001101/phs001101.v1.p1/manifest/Study_Report.phs001101.MIGen_Malmo.v1.p1.MULTI.pdf","ftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001101/phs001101.v1.p1/release_notes/Release_Notes.phs001101.MIGen_Malmo.v1.p1.MULTI.pdf","ftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001101/phs001101.v1.p1/manifest/manifest_phs001101.MIGen_Malmo.v1.p1.c1.HMB-MDS.pdf"],"Xml":["ftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001101/phs001101.v1.p1/pheno_variable_summaries/phs001101.v1.pht005367.v1.p1.MIGen_MDC_Subject_Phenotypes.var_report.xml","ftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001101/phs001101.v1.p1/GapExchange_phs001101.v1.p1.xml","ftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001101/phs001101.v1.p1/pheno_variable_summaries/phs001101.v1.pht005366.v1.MIGen_MDC_Sample.data_dict.xml","ftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001101/phs001101.v1.p1/pheno_variable_summaries/phs001101.v1.pht005368.v1.p1.MIGen_MDC_Sample_Attributes.var_report.xml","ftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001101/phs001101.v1.p1/pheno_variable_summaries/phs001101.v1.pht005365.v1.MIGen_MDC_Subject.data_dict.xml","ftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001101/phs001101.v1.p1/pheno_variable_summaries/phs001101.v1.pht005368.v1.MIGen_MDC_Sample_Attributes.data_dict.xml","ftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001101/phs001101.v1.p1/pheno_variable_summaries/phs001101.v1.pht005367.v1.MIGen_MDC_Subject_Phenotypes.data_dict.xml","ftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001101/phs001101.v1.p1/pheno_variable_summaries/phs001101.v1.pht005366.v1.p1.MIGen_MDC_Sample.var_report.xml","ftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001101/phs001101.v1.p1/pheno_variable_summaries/phs001101.v1.pht005365.v1.p1.MIGen_MDC_Subject.var_report.xml"],"Other":["ftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001101/phs001101.v1.p1/pheno_variable_summaries/datadict_v2.xsl","ftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001101/phs001101.v1.p1/dbGaPEx2.1.5.xsd","ftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001101/phs001101.v1.p1/pheno_variable_summaries/varreports_v3.xsl"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomic"],"study_type":["Case-Control"],"name_synonyms":["T28J14.220, AW060611, EXS, SCYA22, interdigitating cell, ADAM 11, CD11c+CD123- DC, and cysteine-rich protein, ABCD-1, EXCESS MICROSPOROCYTES1, Metalloproteinase-like, MDC, Mdc, mDC, veiled cell, T28J14_220, STCP-1, Scya22, DCBCK, disintegrin-like, CMD, EXTRA SPOROGENOUS CELLS, congenital MD, DC|B-CK."],"study_inc_exc":["
We performed a nested case-control experiment for incident cardiovascular events. Cardiovascular events are defined as myocardial infarction, coronary revascularization, or stroke. We included participants who passed the following sample quality control measures: contamination < 5%, missingness < 5%, concordance with genome-wide array data when available, and Ti/Tv, total variants / depth, and F inbreeding coefficient outliers. We also excluded individuals who were genotypically found to be within three degrees of relatedness.
Cases include those who developed cardiovascular events after a median follow-up of 17.1 years. We excluded individuals who had clinical cardiovascular disease at baseline examination. Controls were matched to each case in the matched nested case-control experiment. Controls were matched for age (+/- 2 years), sex, smoking status, type 2 diabetes status.
"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001101"],"study_history":[null],"attribution":["Principal Investigator - Stacey Gabriel, PhD - Broad Institute, Boston, MA, USA","Co-Investigator - Sekar Kathiresan, MD - Broad Institute and Massachusetts General Hospital, Boston, MA, USA"],"repository":["dbGaP"],"description_synonyms":["Cardiovascular Disorders, malignant Growth, ASCVD, Cardiovascular system disease, Other diseases of pericardium (disorder), IL1BC, Cardiovascular disease, Complete Exome, Other pericardial disease NOS (disorder), cell type cancer, disorder of cardiovascular system, DrIce, DrICE, cardiovascular system disease or disorder, Other heart disease (disorder), CASP-1, Other heart disease NOS (disorder), Cardiovascular disorder, PAPILLARY MUSCLE DIS NEC, CG7788, crice, Risk Factor Score, Other diseases of pericardium, broad, Other disorders of papillary muscle, Cardiovascular Disease (CVD), [X]Other specified diseases of pericardium (disorder), unspecified (disorder), Disorder of cardiovascular system (disorder), [X]Cardiovascular disease, unspecified, Risk Factors, Certain sequelae of myocardial infarction, Disease of cardiovascular system (disorder), cardiovascular disorder, whole exome sequencing, Other heart disease NOS, disease or disorder of cardiovascular system, Diets, CVD, Whole Transcriptome, Transcriptome Sequencing, Other ill-defined heart disease NOS (disorder), Il1bc, neoplasm, Unspecified circulatory system disorder, malignant tumour, Risk Factor, Correlates, study, Cardiovascular Diseases, WES, Other diseases of endocardium (disorder), Complete, Populations at Risk, Exome Sequencings, [X]Other specified diseases of pericardium, DISEASES OF THE CIRCULATORY SYSTEM, reactivo, Complete Exome Sequencing, neoplasm (disease), [X]Other forms of heart disease (disorder), Whole Transcriptome Sequencing, dtom40, PCE-2, Other heart disease, Other ill-defined heart disease (disorder), Risk Score, Other diseases of endocardium, Other forms of heart disease, Cardiovascular Disorder, mit, circulatory system disease, disease of cardiovascular system, Other specified pericardial disease NOS, Sequencing, IL-1BC, CA, Population at Risk, Social, cardiovascular disease, Whole Exome, Disorder of cardiovascular system, Caspase-1 subunit p20, malignant neoplasm, Health Correlates, ICE, Whole, Social Risk Factor, Disease of cardiovascular system, ms15, Circulatory system disease NOS, reagents, OTHER SEQUELAE OF MI NEC, targeted exome capture, malignancy, Circulatory system disease NOS (disorder), Disease, HiSeq 2000., Other ill-defined heart diseases, Complete Exome Sequencings, wide/broad, Caspase-1 subunit p10, ice, iCE, drice, caspase 3, malignant, not elsewhere classified, l(1)G0216, Exome, Disorder of circulatory system, Factor, Disease affecting entire cardiovascular system (disorder), CE-2, Risk Factor Scores, Other ill-defined heart disease, disease of subdivision of hemolymphoid system, cardiovascular disease (CVD), DmelCG7788, Exome Sequencing, MT, drIce, drICE, Ill-defined descriptions and complications of heart disease, malignant neoplasm (disease), organ system cancer, Diseases, sequence, Score, NOS, Other pericardial disease NOS, CES2A1, Other forms of heart disease (disorder), Other ill-defined heart disease NOS, reactif, PERICARDIAL DISEASE NEC, CIRCULATORY DISEASE NOS, CARDIOVASC DIS, Other specified diseases of pericardium, Complete Transcriptome, primary cancer, Cardiovascular, Factors, Complete Transcriptome Sequencing, Social Risk Factors, Risk, [X]Other ill-defined heart diseases, P45, Disorder of the circulatory system, [X]Other forms of heart disease, reagent, [X]Other ill-defined heart diseases (disorder), IL-1 beta-converting enzyme, tom40, Interleukin-1 beta-converting enzyme, Other sequelae of myocardial infarction, malignant tumor, CG12157, primary structure of sequence macromolecule, Risk Scores, CVS disease, Interleukin-1 beta convertase, Social Risk, cardiovascular system disease, Other specified pericardial disease NOS (disorder), wide, Health, DmelCG12157, malignant neoplastic disease, ILL-DEFINED HRT DIS NEC, Drice, Whole Exome Sequencing, 3.4.22.36, p45, ms(1)15, Disease affecting entire cardiovascular system, DRICE, cancer, Transcriptome Sequencings"],"additional_accession":[]},"is_claimable":false,"name":"MIGen_ExS: MDC","description":"The Malmo Diet and Cancer Study (MDCS) is a community-based prospective epidemiologic cohort of 28,449 subjects who were recruited for baseline examination between 1991 and 1996. From this cohort, 6103 subjects were randomly selected to participate in a cardiovascular cohort (MDCSCC), which seeks to investigate risk factors for cardiovascular disease. This study is a subset of those samples.
All exome sequencing was performed at the Broad Institute of Harvard and MIT; samples sequence capture was performed using Illumina's ICE Capture reagent and sequencing was performed on an Illumina HiSeq 2000 or 2500.
","dates":{"last_modification":"2016-03-29","creation":"2016-03-29"},"accession":"phs001101","cross_references":{"MESH":["Myocardial Infarction"]}}