dbGaPapplication/xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001271/phs001271.v1.p1/manifest/Study_Report.phs001271.KidneyCancer_PooledGWA.v1.p1.MULTI.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001271/phs001271.v1.p1/release_notes/Release_Notes.phs001271.KidneyCancer_PooledGWA.v1.p1.MULTI.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001271/phs001271.v1.p1/manifest/manifest_phs001271.KidneyCancer_PooledGWA.v1.p1.c2.DS-CA-NPU-GSO.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001271/phs001271.v1.p1/manifest/manifest_phs001271.KidneyCancer_PooledGWA.v1.p1.c1.HMB-PUB-NPU-MDS.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001271/phs001271.v1.p1/manifest/manifest_phs001271.KidneyCancer_PooledGWA.v1.p1.c3.DS-RCC-MDS.pdfftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001271/phs001271.v1.p1/pheno_variable_summaries/phs001271.v1.pht006118.v1.KIDRISK_Subject_Phenotypes.data_dict.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001271/phs001271.v1.p1/pheno_variable_summaries/phs001271.v1.pht006118.v1.p1.KIDRISK_Subject_Phenotypes.var_report.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001271/phs001271.v1.p1/pheno_variable_summaries/phs001271.v1.pht006117.v1.p1.KIDRISK_Sample.var_report.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001271/phs001271.v1.p1/pheno_variable_summaries/phs001271.v1.pht006116.v1.p1.KIDRISK_Subject.var_report.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001271/phs001271.v1.p1/pheno_variable_summaries/phs001271.v1.pht006119.v1.KIDRISK_Sample_Attributes.data_dict.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001271/phs001271.v1.p1/pheno_variable_summaries/phs001271.v1.pht006117.v1.KIDRISK_Sample.data_dict.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001271/phs001271.v1.p1/GapExchange_phs001271.v1.p1.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001271/phs001271.v1.p1/pheno_variable_summaries/phs001271.v1.pht006119.v1.p1.KIDRISK_Sample_Attributes.var_report.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001271/phs001271.v1.p1/pheno_variable_summaries/phs001271.v1.pht006116.v1.KIDRISK_Subject.data_dict.xmlftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001271/phs001271.v1.p1/pheno_variable_summaries/varreports_v3.xslftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001271/phs001271.v1.p1/pheno_variable_summaries/datadict_v2.xslftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs001271/phs001271.v1.p1/dbGaPEx2.1.5.xsdprimaryOK200GenomicCase-ControlCase-Cohortkidney neoplasm (disease), wide/broad, determination, malignant tumour of the kidney, Neoplasms, KIDNEY NEOPL, malignant kidney tumor, renal tumors, Kidney Neoplasm, neoplasm of the kidney, kidney tumour, broad, renal neoplasm, Kidney Neoplasms, Relative, Cancer of the Kidney, renal tumours, kidney (including renal cell) cancer, Renal cancer, Cancer of Kidney, tumour of kidney, chemical analysis, Neoplasm, neoplasm of kidney, kidney cancer, Kidney Cancers, malignant renal tumour, renal tumour, renal tumor, Renal Cancers, Kidney Cancer, cancer of kidney, Relative Risk, malignant tumour of kidney, malignant renal neoplasm, Renal Neoplasms, RENAL NEOPL, renal cancer, Risk, Genomes, tumour of the kidney, tumor of kidney, Relative Risks., Kidney, Risks, pooled, Renal, whole genome, Cancers, Renal Cancer, NEOPL KIDNEY, wide, kidney neoplasm, kidney tumor, kidney (renal) cancer, tumor of the kidney, malignant tumor of kidney, malignant tumor of the kidney, malignant neoplasm of kidney, assay, malignant renal tumor, malignant kidney neoplasm, malignant neoplasm of the kidney, Renal Neoplasm, malignant neoplasm of kidney except pelvis, malignant kidney tumour, Cancer<p>Cases with ICD code C64.9<br/> Controls were cancer free subjects<br/> Unrelated subjects with more than 70% Caucasian ancestry were kept in final dataset.</p>https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001271<p>The genotyping was centrally performed at the Centre National de Genotypage (Evry, France) from April 2013 to July 2014.</p>Co-Investigators - Lenka Foretova, MD, PhD - Masaryk Memorial Cancer Institute, Brno, Czech RepublicCo-Investigators - Vladimir Janout, MD, PhD - Palacky University, Olomouc, Czech RepublicCo-Investigators - Gordana Basta-Jovanovic, MD - University of Belgrade, Belgrade, SerbiaCo-Investigators - Heiner Boeing, PhD - German Institute of Human Nutrition (DIfE) Potsdam-Rehbrücke, Nuthetal, GermanyCo-Investigators - Olivier Cussenot, MD, PhD - CeRePP, Tenon Hospital, Paris, FranceCo-Investigators - Alicja Wolk, PhD - Karolinska Institutet, Stockholm, SwedenCo-Investigators - Dana Mates, MD, PhD - National Institute of Public Health, Bucharest, RomaniaCo-Investigators - James D McKay, PhD - International Agency for Research on Cancer (IARC), Lyon, FrancePrincipal Investigator - Ghislaine Scélo, PhD - International Agency for Research on Cancer (IARC), Lyon, FranceCo-Investigators - Ivana Holcatova, MD, PhD - Charles University, Prague, Czech RepublicCo-Investigators - Gianluca Severi, PhD - Cancer Council Victoria, Melbourne, AustraliaCo-Investigators - David Zaridze, MD, PhD - Russian N.N. Blokhin Cancer Research Centre, Moscow, Russian FederationCo-Investigators - Jean-Francois Deleuze, PhD - Centre National de Genotypage, Institut de Genomique, Commissariat à l'Energie Atomique et aux Energies Alternatives, Evry, FranceCo-Investigators - Mark Lathrop, PhD - McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, CanadaCo-Investigators - Börje Ljungberg, MD, PhD - Umeå University, Umeå, SwedenFunding Source - U01CA155309 - National Institutes of Health, Bethesda, MD, USACo-Investigators - Paul Brennan, PhD - International Agency for Research on Cancer (IARC), Lyon, FrancedbGaPAdenocarcinoma, Genome-Wide Association, Psychological Power, other disease, Eastern Europe, clear cell renal cell adenocarcinoma, Collecting Duct, Professional Power, Incidences, acetylglucosaminyltransferase-like protein, Genome Wide Association Analysis, Whole Genome Association Study, Renal Cell Cancers, Mbp1, Person-time Rates, Proportion, adenocarcinoma of kidney, Renal Adenocarcinomas, broad, Tumor, Papillary Renal Cell Carcinoma, LARGE1, CCRCC, froggy, Gyltl1a, Secondary Attack Rate, Northern Europe, Personal, Hypernephroid, Rate, Adenocarcinoma Of Kidneys, GWA Studies, Renal Cell Adenocarcinomas, diseases, Sarcomatoid Renal Cell Carcinoma, Studies, disease or disorder, RCC, Hypernephroid Carcinomas, diseases and disorders, Incidence Rate, Renal Carcinomas, Attack Rates, Hypernephroid Carcinoma, myd, Southern Europe, hypernephroma, Grawitz Tumor, Psychological, study, GWA Study, Canton and Enderbury Islands., human disease, Hypernephromas, like-acetylglucosaminyltransferase, Genomes, occurrence, MDDGB6, Collecting Duct Carcinoma, GWA, prevalence, Mbp-1, Renal, LARGE, Genome Wide Association Scan, Genome-Wide Association Studies, non-neoplastic, Social, genetic, Study, Cumulative, BPFD#36, clear cell renal cell carcinoma, Person-time, Person time Rate, disorder, Homo sapiens disease, Renal Collecting Duct Carcinoma, Incidence Proportions, Social Power, Collecting Duct Carcinomas (Kidney), constitutitional genetic, incidence, Power, Grawitz, Cancer, Carcinoma, Adenocarcinoma Of, wide/broad, gyltl1b-b, Attack Rate, Cumulative Incidence, frequency, Incidence, Chromophil Renal Cell Carcinoma, Collecting Duct Carcinomas, disorders, familial, Renal Cell Carcinomas, Secondary Attack, Renal Cell Adenocarcinoma, medical condition, Renal Adenocarcinoma, Adenocarcinoma Of Kidney, Psychological Powers, Renal Cell Carcinoma, Adenocarcinomas, Genome-Wide, Cumulative Incidences, Chromophobe Renal Cell Carcinoma, Collecting Duct Carcinoma of the Kidney, Incidence Rates, renal cell adenocarcinoma, Clear Cell Renal Cell Carcinoma, Genome Wide Association Study, MDDGA6, mKIAA0609, Diseases, Western Europe, condition, Professional, Nephroid Carcinomas, Whole Genome Association Analysis, Person-time Rate, KIAA0609, Hypernephroma, outbreaks, acetylglucosaminyltransferase-like 1A, Carcinomas, fg, Christmas Island (Australia), kidney adenocarcinoma, gyltl1b, Renal Cell, Renal Carcinoma, Kidney, mdc1d, whole genome, Nephroid, surveillance, LARGE_HUMAN, morbidity, endemics, Renal Cell Cancer, Genome Wide Association Studies, Papillary, Secondary, MDC1D, disease, Incidence Proportion, Personal Power, wide, like-glycosyltransferase, enr, Attack, Collecting Duct Carcinoma (Kidney), Collecting Duct (Kidney), Power (Psychology), Association Studies, renal cell carcinoma, epidemics, inherited genetic, Association Study, Secondary Attack Rates, Powers, Nephroid Carcinoma, hereditary, glycosyltransferase-like protein LARGE1, Clear Cell Renal CarcinomafalsePooled Genome-Wide Analysis of Kidney Cancer Risk (KIDRISK)<p>Incidence rates of renal cell carcinoma (RCC) are rising and the latest estimates show that it accounts for over 300,000 cases and 120,000 deaths worldwide each year. Mechanisms underlying RCC occurrence are not fully understood and a large part of the disease heritability remains unexplained. The study aimed at augmenting the size of available RCC genome-wide association studies to increase the statistical power to detect genetic variants associated with the disease. The study includes genome-wide genotyping data from RCC cases (n=2,781) and controls (n=2,526) recruited in Western Europe, Central and Eastern Europe, and Australia.</p>2017-01-272017-01-23phs001271Kidney Neoplasms