Included Ewing sarcoma cases were confirmed by medical record review and when possible confirmation of a EWSR1-ETS translocation. Any cases with <80% genotype estimated percent European ancestry were excluded from the analysis.
"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001549"],"study_history":["This study is from a genome-wide meta analysis of Ewing sarcoma which includes external data from a previously published GWAS as well as data from the Childhood Cancer Survivor Study (CCSS).
"],"attribution":["Principal Investigators - Javed Khan - National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","Principal Investigators - Olivier Delattre - Institut Curie, Paris, France","Principal Investigators - Stephen Chanock - National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","Principal Investigators - Mitchell Machiela - National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","Principal Investigators - Robert Hoover - National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"],"repository":["dbGaP"],"description_synonyms":["Ewing's family localized tumor, localized Ewing's sarcoma/peripheral primitive neuroectodermal tumor, IPP2A2, Activity, determination, Laboratory, Wound, PNT-P1, Ewing's sarcoma, DmelCG17077, CG6338, Physical, crotonyl-coenzyme A reductase activity, Consent, EY3-1, Pnt, Tumor, injury, trauma, d-elg, 5730420M11Rik, Techniques, png, Ewing's tumour, Method, EWSR1, Research Activity, D-ets-2, 3520, Laboratory Research, Research-Related, Ewings Tumor, Pnt-P1, Priorities, Multicase, SET, Ewing's sarcoma/peripheral primitive neuroectodermal tumour, D-elg, thymus nucleic acid, TAF-I, NCPR, procedures, CG3606, localized Ewing's tumor, Ewing's Family of Tumours, DmelCG4299, IGAAD, set, Sarcoma, Methodological Studies, method used in an experiment., DmelCG10574, malignant neoplasm, scientific observation, localised Ewing's sarcoma/peripheral primitive neuroectodermal tumour, peripheral primitive neuroectodermal tumor, Malignancies, Double-Stranded DNA, Research Priority, deoxyribonucleic acids, Pen19, DNAn, TL, P19, Tumors, phapii, Elg, Ewsh, anon-Pen19, Injury and Wounds, localised Ewing's tumour, StF-IT-1, Salivas, Research Priorities, DmelCG11567, Physical Traumas, D-Ets-2, ets94F, 0123/09, Double-Stranded, localised Ewing's sarcoma, p19, Procedure, localized peripheral primitive neuroectodermal tumor, elg, (Deoxyribonucleotide)n+m, Bone Disease, D-Elg, DmelCG6338, Ewings Sarcoma, Ewing's Sarcoma, Benign, ES, Diseases, Physical Trauma, desoxyribose nucleic acid, Ewings sarcoma-primitive neuroectodermal tumour, Research and Development, pntP2, bK984G1.4, skeletal disease, HLA-DR-associated protein II, Pointed-P1, rare bone disease related to a common gene or pathway defect, DI-2, NCI (US), Review, neuroepithelioma, I-2Dm, Ewing Tumor, Ets94F, Benign Neoplasms, CG4299, Methodological, National Cancer Institute, study protocol, Methodological Study, Ewings, Malignant Neoplasms, I-2PP1, Activities, ptd, PntP2, TAF-IBETA, DMR, PntP1, E(E2F)3D, localized Ewing's sarcoma, ds DNA, Ewing tumor, DmelCG3606, Ewing's sarcoma (morphologic abnormality), localized Ewing sarcoma, Research-Related Injuries, microarray, TAF-Ibeta, PNTP2, Research-Related Injury, Review of Reported Cases, DNA, i2pp2a, Ewing Sarcoma, Bone, PNTP1, peripheral primitive neuroectodermal tumour, Research Related Injuries, 0998/12, criteria, DNS, Procedures, (Deoxyribonucleotide)n, Neoplasms, ETS2, Ets2, localised Ewing sarcoma, Benign Neoplasm, number, guidelines, Malignant, Injuries and Wounds, presence, PHAPII, Deoxyribonucleic acids, method, DMPOINT1A, pntegfr, 0608/07, Wounds, Deoxyribonucleic Acid, tne, Studies, saliva molecularis, SARFH, Sarfh, Technique, tny, study, Injury, pointed-RC, Malignancy, Research, Academic, ipp2a2, saliva atomaris, 2pp2a, Double Stranded, Deoxyribonucleic acid, pen19, P450, CG10574, EK3-2, Ewing's Tumor, Neoplasias, Study, l(3)07825, 2PP2A, taf-ibeta, Informed, Traumas, dSET, dSet, Ewing's tumor, CG17077, Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Development and Research, (Deoxyribonucleotide)m, l(3)j1B7, Cancer, Ewing's Family of Tumors, CG11567, measuring, sarcoma, CPR, Disease, Ets, Malignant Neoplasm, whole blood, DNAn+1, igaad, \"skeletal disease\" RELATED [], Ewing Family of Tumors, BcDNA:GM09207, Cell, AU018891, group, peripheral, Ewing's sarcoma/peripheral primitive neuroectodermal tumor, DELG, PNET of Thoracopulmonary Region, cpr, count in organism, Priority, MT, Review Literature, I-2PP2A, traumatic injury, Wounds and Injury, Trauma, Dm I-2, chemical analysis, I2PP2A, Research Activities, Tumors of the Ewing's Family, Neoplasm, TFIID, techniques, ds-DNA, pnt-P1, pnt-P2, l(3)s118306, Caz, Ewing tumour, Ewing sarcoma, primary cancer, localised peripheral primitive neuroectodermal tumour, ensemble, Ewings sarcoma-primitive neuroectodermal tumor, DmCPR, Ewings sarcoma, wound, Ewing, cas, Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Cancers, malignant tumor, Injuries, Ews, EWS, plan specification, dSET/TAF-Ibeta, 2610030F17Rik, Ewing's, Ets58AB, Desoxyribonukleinsaeure, CCR, sailva normalis, assay, AA407739, Neoplasia, POINT, Delg, methodology, CG8705"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide Association Study and Meta-Analysis of Ewing Sarcoma","description":"We combined a set of 122 French Ewing sarcoma (EWS) cases from the Institut Curie, 19 EWS cases from the National Cancer Institute (NCI) Center for Cancer Research (CCR), and 29 EWS cases from the NCI Bone Disease and Injury Study. All EWS cases were confirmed by medical record review and the presence of a specific EWSR1-ETS translocation were noted when data was available. Each participant provided informed consent and each participating study was approved by the Institutional Review Boards of their study center. DNA was extracted using standard methods from blood, saliva (Oragene), or buccal cells. All de novo genotyping of EWS cases was performed at the NCI CGR on the Illumina OmniExpress-24 v1.1 array. Genotyping was performed according to manufacturer's guidelines using the Infinium HD Assay automated protocol.
","dates":{"last_modification":"2018-03-08","creation":"2018-02-15"},"accession":"phs001549","cross_references":{"MESH":["Sarcoma, Ewing"]}}