All patients undergoing surgical resection for sporadic parathyroid cancer at a tertiary cancer center over a 25-year period were identified. Patients with sporadic parathyroid cancer according to World Health Organization diagnostic criteria and with available tumor tissue were included in the study. Patients with parathyroid tumors of uncertain malignancy or atypical parathyroid neoplasms were excluded.
"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001765"],"study_history":[null],"attribution":["Funding Source - T32CA009599-24 - National Institutes of Health, Bethesda, MD, USA","Principal Investigator - Nancy Dugal Perrier, MD, FACS - The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"repository":["dbGaP"],"description_synonyms":["Cdc73, carcinoma of parathyroid, type 1, malignant tumor of the parathyroid, Materials, Complete Exome Sequencings, malignant parathyroid tumor, HPTJT, Complete Exome, carcinoma of parathyroid gland, MEN1., endocrine adenomatosis multiple, Exome, Gene, 8430414L16Rik, carcinoma of the parathyroid gland, BC027756, Cistrons, malignant neoplasm of parathyroid gland, Menin1, endocrine adenomatosis, Exome Sequencing, CG13778, MEA 1, carcinoma of the parathyroid, malignant parathyroid neoplasm, FIHP, C130030P16Rik, parathyroid carcinoma, malignant parathyroid gland neoplasm, MEN1 somatic mutations, Genetic Materials, parathyroid cancer, Whole Transcriptome, Transcriptome Sequencing, DmelCG13778, malignant neoplasm of parathyroid, parathyroid gland neoplasm, Genetic Material, SCG2, CG11990, WES, Complete Transcriptome, Complete, Complete Transcriptome Sequencing, Exome Sequencings, Genetic, DmelCG11990, epithelial body, Complete Exome Sequencing, Whole Transcriptome Sequencing, PRTC, multiple endocrine neoplasia, menin, adenocarcinoma of parathyroid, malignant tumor of the parathyroid gland, adenocarcinoma of parathyroid gland, parathyroid gland adenocarcinoma, mnn1, malignant tumor of parathyroid, parathyroid gland cancer, malignant neoplasm of the parathyroid gland, Sequencing, C81219, parathyroid neoplasm, MEAI, Whole Exome, malignant neoplasm of the parathyroid, Hyx, HYX, Hrpt2, multiple, Material, parathyroid, C1orf28, parathyroid gland carcinoma, Whole, malignant parathyroid gland tumor, Whole Exome Sequencing, Cistron, AW045611, parathyroid secreting cell, cancer of parathyroid gland, adenocarcinoma of the parathyroid gland, cancer of the parathyroid gland, HRPT2, Transcriptome Sequencings, adenocarcinoma of the parathyroid, hyx/CDC73, parathyroid adenocarcinoma, HRPT1, CG33266"],"additional_accession":[]},"is_claimable":false,"name":"Genomic Characterization of Parathyroid Cancer","description":"Here we performed genomic characterization of twenty-nine sporadic parathyroid cancers using next generation whole exome sequencing. Thirty-three novel candidate driver genes for sporadic parathyroid cancer were proposed, in addition to previously known driver genes CDC73 and MEN1.
","dates":{"last_modification":"2019-01-03","creation":"2019-01-03"},"accession":"phs001765","cross_references":{"MESH":["Parathyroid Neoplasms"]}}