ecrin-mdr-crcClinical2023Neoplasm MetastasisLiver NeoplasmsFor Patients With Colorectal Cancer Liver Metastases Who Were Not Able to Curative Surgical Resection.Focused on the Treatment Effect With the Quintuple MethodNeoplasm MetastasisLiver NeoplasmsFor Patients With Colorectal Cancer Liver Metastases Who Were Not Able To Curative Surgical Resection.focused On The Treatment Effect With The Quintuple MethodInterventionalhttps://newmdr.ecrin.org/Study/11945China3Folic AcidVitamin AOxaliplatinTegafurMetronidazoleCetuximabColorectal Liver MetastasesQuintuple methodECRIN MDRNot yet recruitingfalseQuintuple Method for Treatment of Multiple Refractory Colorectal Liver MetastasesThe aim of this study is to explore the therapeutic effect of Quintuple method in the treatment of patients with multiple and refractory liver metastases from colorectal cancer. A randomized single-arm clinical trial was conducted.The intervention group was treated with single SOX chemotherapy, SOX chemotherapy combined with cetuximab targeted therapy, SOX chemotherapy combined with low-dose cetuximab targeted therapy combined with three-drug regimen（Quintuple method）, and the RECIST 1.1 solid tumor evaluation criteria were used to assess the disease.2023-03-1511945NCT05774964