ecrin-mdr-crcClinical2022IPD Sharing (as of May 2023): Yes Description: A part of the omics analysis data obtained in the analysis of this study may be disclosed through public databases such as the "Human Database" operated by National Bioscience Database Center (NBDC) in Japan Science and Technology Agency (JST). When registering data, re-anonymization will be provided to strengthen the protections of personal information. At the time of NBDC registration, we will comply with the "NBDC Guidelines for Human Data Sharing" and "NBDC Security Guidelines for Human Data(for Data Providers)" .Rectal NeoplasmsColorectal NeoplasmsLocally Advanced Rectal CancerRectal NeoplasmsColorectal NeoplasmsLocally Advanced Rectal CancerInterventionalhttps://newmdr.ecrin.org/Study/2068Japan11RestagingGastrointestinal NeoplasmsNon-operative managementRectal cancerCapecitabineMRIRadiationAntineoplastic AgentsCAPOXIRIQOLIrinotecanChemotherapyOxaliplatinOrgan preservationCAPOXIntestinal NeoplasmsDigestive System NeoplasmsTotal neoadjuvant therapyECRIN MDRRecruitingfalseTotal Neoadjuvant Therapy of SCRT+CAPOX vs SCRT+CAPOXIRI for Locally Advanced Rectal Cancer (ENSEMBLE)This trial is a multicenter randomized Phase III study to verify the superiority of short-course preoperative radiation (SCRT) and CAPOXIRI over SCRT and CAPOX as preoperative treatments for locally advanced rectal cancer.2022-11-152068NCT05646511jRCTs031220342JPRN-jRCTs031220342