ecrin-mdr-crcClinical2020IPD Sharing (as of October 2023): NoProphylactic surgerypazienti affetti da tumore del colon-retto (CRC) ad alto rischio di sviluppare carcinosi peritonealeColorectal cancerColon neoplasmColorectal Neoplasmspatients with colorectal carcinoma at high risk peritoneal carcinomatosisPazienti Affetti Da Tumore Del Colon-retto (crc) Ad Alto Rischio Di Sviluppare Carcinosi PeritonealeColon NeoplasmColorectal CancerColorectal NeoplasmsPatients With Colorectal Carcinoma At High Risk Peritoneal CarcinomatosisProphylactic SurgeryInterventionalhttps://newmdr.ecrin.org/Study/2302856Italy6MitomycinsMitomycinHIPEC CO2ECRIN MDRRecruitingfalseProphylactic Surgery Plus HIPEC With CO2 in Patients Affected by Colorectal Carcinoma. CHECK Study.This is a phase III randomized, multicenter study with two different arm: * experimental: prophylactic surgery plus HIPEC CO2 performed with mitomycin * comparator: standard surgery Adjuvant treatment after surgery is mandatory except for documented cases of non-eligibility. Patient will be randomized in a 1:1 ratio. Randomization will be done during surgery if the total resection of tumour will be reached and will use a stratification procedure based on center2020-06-152302856NCT039148202019-001437-14