ecrin-mdr-crcClinical2021Sarcoma, EwingCarcinomaRefractory Non-Hodgkin LymphomaRefractory Desmoid FibromatosisRecurrent Desmoid FibromatosisFibromaNeuroblastomaEndometrial NeoplasmsRecurrent Non-Hodgkin LymphomaPancreatic Ductal AdenocarcinomaNeoplasmsColorectal CarcinomaRefractory Hepatocellular CarcinomaLymphoma, Non-HodgkinRecurrent HepatoblastomaRecurrent Malignant Solid NeoplasmFibromatosis, AggressiveOsteosarcomaOvarian CarcinomaColorectal NeoplasmsRecurrent Ewing SarcomaPancreatic NeoplasmsHepatoblastomaRefractory OsteosarcomaRefractory HepatoblastomaSarcomaSolid Pseudopapillary Neoplasm of the PancreasMelanomaRecurrent Hepatocellular CarcinomaRefractory Malignant Solid NeoplasmLymphomaRecurrent OsteosarcomaRefractory Ewing SarcomaWilms TumorCarcinoma, HepatocellularEndometrial CarcinomaSarcoma, EwingCarcinomaRefractory Desmoid FibromatosisSolid Pseudopapillary Neoplasm Of The PancreasRecurrent Desmoid FibromatosisNeuroblastomaEndometrial NeoplasmsFibromaPancreatic Ductal AdenocarcinomaNeoplasmsColorectal CarcinomaRefractory Hepatocellular CarcinomaRecurrent HepatoblastomaRecurrent Malignant Solid NeoplasmFibromatosis, AggressiveOsteosarcomaOvarian CarcinomaColorectal NeoplasmsRecurrent Ewing SarcomaPancreatic NeoplasmsHepatoblastomaRefractory Non-hodgkin LymphomaRefractory OsteosarcomaRefractory HepatoblastomaSarcomaMelanomaRecurrent Hepatocellular CarcinomaRefractory Malignant Solid NeoplasmLymphomaRecurrent Non-hodgkin LymphomaRecurrent OsteosarcomaRefractory Ewing SarcomaLymphoma, Non-hodgkinWilms TumorCarcinoma, HepatocellularEndometrial CarcinomaInterventionalhttps://newmdr.ecrin.org/Study/2374785United States11ECRIN MDRRecruitingfalseTegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid TumorsThis phase I/II trial evaluates the highest safe dose, side effects, and possible benefits of tegavivint in treating patients with solid tumors that has come back (recurrent) or does not respond to treatment (refractory). Tegavivint interferes with the binding of beta-catenin to TBL1, which may help stop the growth of tumor cells by blocking the signals passed from one molecule to another inside a cell that tell a cell to grow.2021-11-152374785NCT04851119