ecrin-mdr-crcClinical2005Histologically confirmed adenocarcinoma of the colon or the rectum and unresectable metastases or advanced locoregional diseaseHistologically Confirmed Adenocarcinoma Of The Colon Or The Rectum And Unresectable Metastases Or Advanced Locoregional DiseaseInterventionalhttps://newmdr.ecrin.org/Study/2516699Belgium5ELVORINE, 50mg/5ml, solution for injectionVorina®, 350mg/14ml, solution for injectionFLURACEDYL, 1000mg/20ml, solution for injection; 5000mg/100ml solution for injectionRescuvolin®, 300mg/12ml, solution for injectionECRIN MDRCompletedfalseSFOLFOX/SFOLFIRI vs FOLFOX/FOLFIRIPrimary objectives: The first objective is to evaluate, in terms of Objective Response Rate (ORR), whether the combined infusional Leucovorin Sodium and 5-FU has the potential of being superior to the standard sequential administration of Leucovorin Calcium and 5-FU, both in combination with standard Irinotecan or Oxaliplatin. Primary endpoints: The primary end-point for efficacy is the Objective Response Rate (using RECIST criteria) during the treatment period.2005-05-1525166992004-004901-12