ecrin-mdr-crcClinical2007Colon neoplasmmethastatic colorectal cancerMethastatic Colorectal CancerColon NeoplasmInterventionalhttps://newmdr.ecrin.org/Study/2522056Italy4SONOVUE*1FL 8MCG+1SIR 5ML+ADATECRIN MDRCompletedfalseEarly ultrasonography role by Contrast enhanced ultrasonography ( CEUS) evaluating therapy effectiveness in patients with hepatic metastasis of colorectal cancer treated with antiangiogenetic drug.Primary objectives: assessment, by CEUS, of early response to antiangiogenic treatment in patients with liver mets from colorectal cancer treated by Bevacizumab plus Folfiri every 14 days (or by other protocols including 5FU and Irinotecan plus bevacizumab). Aim: Early assessment of the antiangiogenetic effectiveness of bevacizumab studied by CEUS vs RECIST criteria. Theﾓtargetﾔ lesions are only the ones measurable and the ones susceptible of reiterable measuring in CEUS. After US identification of a ﾓtargetﾔ lesion the microcirculation of which will be evaluated by CEUS. Primary endpoints: Early assessment of the antiangiogenetic effectivenes of bevacizumab studied by CEUS vs RECIST criteria2007-04-1525220562007-001927-36